Placental growth factor blunts uterine artery responses to angiotensin II

Objective Changes in maternal serum concentration of placental growth factor (PlGF) and vascular response to intravascular infusion of Angiotensin II (Ang II) follow a bell‐shaped curve pattern during gestation. This study evaluates the effects of PlGF and soluble vascular endothelial growth factor...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2019-07, Vol.126 (8), p.1058-1064
Main Authors: Espinoza, J, Betancourt, A, Belfort, MA, Shamshirsaz, AA, Fox, KA, Yallampalli, C
Format: Article
Language:English
Subjects:
Adult
Angiotensin
Angiotensin II
Angiotensin II - pharmacology
Arteries
Blood Pressure
Charybdotoxin
Contraction
Endothelium
Female
Gestation
Humans
Hysterectomy
Physical growth
Placenta
Placenta Growth Factor - metabolism
placental growth factor
Pregnancy
response
sFlt‐1
Uterine Artery - drug effects
Uterus
vascular
Vascular endothelial growth factor
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Vasoconstrictor Agents - pharmacology
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Summary:Objective Changes in maternal serum concentration of placental growth factor (PlGF) and vascular response to intravascular infusion of Angiotensin II (Ang II) follow a bell‐shaped curve pattern during gestation. This study evaluates the effects of PlGF and soluble vascular endothelial growth factor receptor‐1 (sFlt‐1) on responses of human uterine arteries (UA) to Ang II. Design Experimental. Setting Baylor College of Medicine and Texas Children's Hospital‐Pavilion for Women. Sample Uterine arteries samples (n = 14) were obtained from normotensive women undergoing caesarean hysterectomy at ≥32 weeks. Methods Uterine arteries rings were incubated with (1) Krebs solution; (2) PlGF at 1.45, 14.5, and 500 pg/ml; (3) sFlt‐1 at 2 ng/ml; and (4) a combination of sFlt‐1, and PlGF. Dose‐contraction responses to Ang II were determined in UA rings incubated in the above‐mentioned conditions. Responses were also measured in presence of L‐NAME or inhibitors of endothelium‐derived hyperpolarising factor: apamine and charybdotoxin. The t‐test was used for comparisons. Main outcome measure Changes in vascular reactivity of UA rings. Results PlGF blunted (P = 0.03) and sFlt‐1 increased (P 
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.15656