Loading…
Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children
We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assesse...
Saved in:
| Published in: | Scientific reports 2020-02, Vol.10 (1), p.2238-2238, Article 2238 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93 |
| container_end_page | 2238 |
| container_issue | 1 |
| container_start_page | 2238 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Lyu, In Jeong Park, Kyung-Ah Oh, Sei Yeul |
| description | We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence tomography (OCT). Univariable and multivariable logistic analyses were performed to evaluate risk factors associated with presence of PHOMS. Among the 66 children with PHOMS, 53 (80.3%) had bilateral and 13 (19.7%) had unilateral PHOMS. The mean age of the PHOMS group was 11.7 ± 2.6 years, and that of the control group was 11.4 ± 3.1 years. The mean spherical equivalent (SE) as determined by cycloplegic refraction was −3.13 ± 1.87 diopters (D) in the PHOMS group and −0.95 ± 2.65 D in the control group. Additionally, mean astigmatism was 0.67 ± 0.89 D and 0.88 ± 1.02 D in the PHOMS group and the control group, respectively. Mean disc size was 1,735 ± 153 µm in the PHOMS group and 1,741 ± 190 µm in the control group, while mean optic nerve head (ONH) tilt angle was 9.84 ± 5.38 degrees in the PHOMS group and 3.71 ± 4.41 degrees in the control group. SE and ONH tilt angle were significantly associated with PHOMS according to both univariable [odds ratio (OR): 1.59;
p
|
| doi_str_mv | 10.1038/s41598-020-58829-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7010819</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2352999450</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93</originalsourceid><addsrcrecordid>eNp9kU1PJCEQholxo8b1D3gwJF68tMvnNFxMjNFdExMv65kwdLWDdkML3WPm38s46qqH5QJFPfVSxYvQISWnlHD1KwsqtaoII5VUiumKb6E9RoSsGGds-9N5Fx3k_EDKkkwLqnfQLi9JqjXfQ-485-i8HX0MeA7jM0DA_SoO3mIbGjxA8oMdfNfZtMKLVYkTtB240S8Bx2X0De5tzlXnHwHnMU1unBJk7AN2C981CcJP9KO1XYaDt30f3V1d_r34U93c_r6-OL-pnGRsrPSsraWkjZ1Jq7gQHByomijHy6W2TTujALx2rrZ1K6idCyLsjBCl2dwK0HwfnW10h2neQ-MgjMl2Zki-L82baL35mgl-Ye7j0tSEEkXXAidvAik-TZBH0_vsoMweIE7ZMC65VDVToqDH39CHOKVQxltTTGstJCkU21AuxZzLx300Q4lZ22g2Nppio3m10fBSdPR5jI-Sd9MKwDdALqlwD-nf2_-RfQFvnKrE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2352999450</pqid></control><display><type>article</type><title>Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children</title><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Lyu, In Jeong ; Park, Kyung-Ah ; Oh, Sei Yeul</creator><creatorcontrib>Lyu, In Jeong ; Park, Kyung-Ah ; Oh, Sei Yeul</creatorcontrib><description>We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence tomography (OCT). Univariable and multivariable logistic analyses were performed to evaluate risk factors associated with presence of PHOMS. Among the 66 children with PHOMS, 53 (80.3%) had bilateral and 13 (19.7%) had unilateral PHOMS. The mean age of the PHOMS group was 11.7 ± 2.6 years, and that of the control group was 11.4 ± 3.1 years. The mean spherical equivalent (SE) as determined by cycloplegic refraction was −3.13 ± 1.87 diopters (D) in the PHOMS group and −0.95 ± 2.65 D in the control group. Additionally, mean astigmatism was 0.67 ± 0.89 D and 0.88 ± 1.02 D in the PHOMS group and the control group, respectively. Mean disc size was 1,735 ± 153 µm in the PHOMS group and 1,741 ± 190 µm in the control group, while mean optic nerve head (ONH) tilt angle was 9.84 ± 5.38 degrees in the PHOMS group and 3.71 ± 4.41 degrees in the control group. SE and ONH tilt angle were significantly associated with PHOMS according to both univariable [odds ratio (OR): 1.59;
p
< 0.001 and OR: 1.35;
p
< 0.001, respectively] and multivariable (OR: 1.71;
p
= 0.001 and OR: 1.29;
p
= 0.001, respectively) logistic regression analyses. There was a significant correlation between SE and ONH tilt (
r
= −0.46;
p
< 0.001). In conclusion, PHOMS is associated with myopic shift in children, and optic disc tilt may be a mediator between myopia and PHOMS.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-58829-3</identifier><identifier>PMID: 32041993</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/5 ; 692/499 ; 692/699/3161/3172 ; Adolescent ; Case-Control Studies ; Child ; Children ; Cross-Sectional Studies ; Female ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Male ; multidisciplinary ; Myopia ; Myopia - physiopathology ; Optic Disk - physiopathology ; Optic nerve ; Optic Nerve Diseases - physiopathology ; Retrospective Studies ; Risk factors ; Science ; Science (multidisciplinary) ; Young Adult</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2238-2238, Article 2238</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93</citedby><cites>FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2352999450/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2352999450?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32041993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyu, In Jeong</creatorcontrib><creatorcontrib>Park, Kyung-Ah</creatorcontrib><creatorcontrib>Oh, Sei Yeul</creatorcontrib><title>Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence tomography (OCT). Univariable and multivariable logistic analyses were performed to evaluate risk factors associated with presence of PHOMS. Among the 66 children with PHOMS, 53 (80.3%) had bilateral and 13 (19.7%) had unilateral PHOMS. The mean age of the PHOMS group was 11.7 ± 2.6 years, and that of the control group was 11.4 ± 3.1 years. The mean spherical equivalent (SE) as determined by cycloplegic refraction was −3.13 ± 1.87 diopters (D) in the PHOMS group and −0.95 ± 2.65 D in the control group. Additionally, mean astigmatism was 0.67 ± 0.89 D and 0.88 ± 1.02 D in the PHOMS group and the control group, respectively. Mean disc size was 1,735 ± 153 µm in the PHOMS group and 1,741 ± 190 µm in the control group, while mean optic nerve head (ONH) tilt angle was 9.84 ± 5.38 degrees in the PHOMS group and 3.71 ± 4.41 degrees in the control group. SE and ONH tilt angle were significantly associated with PHOMS according to both univariable [odds ratio (OR): 1.59;
p
< 0.001 and OR: 1.35;
p
< 0.001, respectively] and multivariable (OR: 1.71;
p
= 0.001 and OR: 1.29;
p
= 0.001, respectively) logistic regression analyses. There was a significant correlation between SE and ONH tilt (
r
= −0.46;
p
< 0.001). In conclusion, PHOMS is associated with myopic shift in children, and optic disc tilt may be a mediator between myopia and PHOMS.</description><subject>59/5</subject><subject>692/499</subject><subject>692/699/3161/3172</subject><subject>Adolescent</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Myopia</subject><subject>Myopia - physiopathology</subject><subject>Optic Disk - physiopathology</subject><subject>Optic nerve</subject><subject>Optic Nerve Diseases - physiopathology</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kU1PJCEQholxo8b1D3gwJF68tMvnNFxMjNFdExMv65kwdLWDdkML3WPm38s46qqH5QJFPfVSxYvQISWnlHD1KwsqtaoII5VUiumKb6E9RoSsGGds-9N5Fx3k_EDKkkwLqnfQLi9JqjXfQ-485-i8HX0MeA7jM0DA_SoO3mIbGjxA8oMdfNfZtMKLVYkTtB240S8Bx2X0De5tzlXnHwHnMU1unBJk7AN2C981CcJP9KO1XYaDt30f3V1d_r34U93c_r6-OL-pnGRsrPSsraWkjZ1Jq7gQHByomijHy6W2TTujALx2rrZ1K6idCyLsjBCl2dwK0HwfnW10h2neQ-MgjMl2Zki-L82baL35mgl-Ye7j0tSEEkXXAidvAik-TZBH0_vsoMweIE7ZMC65VDVToqDH39CHOKVQxltTTGstJCkU21AuxZzLx300Q4lZ22g2Nppio3m10fBSdPR5jI-Sd9MKwDdALqlwD-nf2_-RfQFvnKrE</recordid><startdate>20200210</startdate><enddate>20200210</enddate><creator>Lyu, In Jeong</creator><creator>Park, Kyung-Ah</creator><creator>Oh, Sei Yeul</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200210</creationdate><title>Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children</title><author>Lyu, In Jeong ; Park, Kyung-Ah ; Oh, Sei Yeul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>59/5</topic><topic>692/499</topic><topic>692/699/3161/3172</topic><topic>Adolescent</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Children</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Myopia</topic><topic>Myopia - physiopathology</topic><topic>Optic Disk - physiopathology</topic><topic>Optic nerve</topic><topic>Optic Nerve Diseases - physiopathology</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyu, In Jeong</creatorcontrib><creatorcontrib>Park, Kyung-Ah</creatorcontrib><creatorcontrib>Oh, Sei Yeul</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyu, In Jeong</au><au>Park, Kyung-Ah</au><au>Oh, Sei Yeul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-10</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2238</spage><epage>2238</epage><pages>2238-2238</pages><artnum>2238</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence tomography (OCT). Univariable and multivariable logistic analyses were performed to evaluate risk factors associated with presence of PHOMS. Among the 66 children with PHOMS, 53 (80.3%) had bilateral and 13 (19.7%) had unilateral PHOMS. The mean age of the PHOMS group was 11.7 ± 2.6 years, and that of the control group was 11.4 ± 3.1 years. The mean spherical equivalent (SE) as determined by cycloplegic refraction was −3.13 ± 1.87 diopters (D) in the PHOMS group and −0.95 ± 2.65 D in the control group. Additionally, mean astigmatism was 0.67 ± 0.89 D and 0.88 ± 1.02 D in the PHOMS group and the control group, respectively. Mean disc size was 1,735 ± 153 µm in the PHOMS group and 1,741 ± 190 µm in the control group, while mean optic nerve head (ONH) tilt angle was 9.84 ± 5.38 degrees in the PHOMS group and 3.71 ± 4.41 degrees in the control group. SE and ONH tilt angle were significantly associated with PHOMS according to both univariable [odds ratio (OR): 1.59;
p
< 0.001 and OR: 1.35;
p
< 0.001, respectively] and multivariable (OR: 1.71;
p
= 0.001 and OR: 1.29;
p
= 0.001, respectively) logistic regression analyses. There was a significant correlation between SE and ONH tilt (
r
= −0.46;
p
< 0.001). In conclusion, PHOMS is associated with myopic shift in children, and optic disc tilt may be a mediator between myopia and PHOMS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32041993</pmid><doi>10.1038/s41598-020-58829-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-02, Vol.10 (1), p.2238-2238, Article 2238 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7010819 |
| source | Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 59/5 692/499 692/699/3161/3172 Adolescent Case-Control Studies Child Children Cross-Sectional Studies Female Health risk assessment Humanities and Social Sciences Humans Male multidisciplinary Myopia Myopia - physiopathology Optic Disk - physiopathology Optic nerve Optic Nerve Diseases - physiopathology Retrospective Studies Risk factors Science Science (multidisciplinary) Young Adult |
| title | Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T03%3A06%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20myopia%20and%20peripapillary%20hyperreflective%20ovoid%20mass-like%20structures%20in%20children&rft.jtitle=Scientific%20reports&rft.au=Lyu,%20In%20Jeong&rft.date=2020-02-10&rft.volume=10&rft.issue=1&rft.spage=2238&rft.epage=2238&rft.pages=2238-2238&rft.artnum=2238&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-58829-3&rft_dat=%3Cproquest_pubme%3E2352999450%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c522t-96f7551da65a83443ece8708c351d9adf61ee37cc7a7f41ab404a600892ba4e93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2352999450&rft_id=info:pmid/32041993&rfr_iscdi=true |