The Effect of Long-Term Traditional Chinese Medicine Treatment on Survival Time of Colorectal Cancer Based on propensity Score Matching: A Retrospective Cohort Study

Objective. To explore the effect of long-term traditional Chinese medicine (TCM) treatment on survival time of colorectal cancer (hereinafter referred to as CRC). Methods. Our clinical study included patients who were diagnosed with CRC clinically or pathologically. Patients were divided into TCM tr...

Full description

Saved in:
Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-12
Main Authors: Li, Yan, Zhang, Qiang, Zhao, Fanchen, Xu, Jing, Li, Shufang, Tian, Jianhui, Fang, Yuan, Liu, Ping, Wang, Yuli, Yin, Xiaoling
Format: Article
Language:English
Subjects:
Analysis
Cancer
Care and treatment
Cell cycle
Chemotherapy
Chinese medicine
Cohort analysis
Colorectal cancer
Colorectal carcinoma
Diabetes
Evidence-based medicine
Family medical history
Gastrointestinal diseases
Gender
Herbal medicine
Histology
Hospitals
Hypertension
Intestine
Medical prognosis
Medicine, Chinese
Metastases
Metastasis
Oncology, Experimental
Pathology
Patient outcomes
Patients
Regression analysis
Surgery
Survival
Survival analysis
Traditional Chinese medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. To explore the effect of long-term traditional Chinese medicine (TCM) treatment on survival time of colorectal cancer (hereinafter referred to as CRC). Methods. Our clinical study included patients who were diagnosed with CRC clinically or pathologically. Patients were divided into TCM treatment group and control group according to whether the modified Anti-cancer Decoction II Formula was applied for more than six months. Propensity score matching (hereinafter referred to as PSM) was used to further balance the covariates between groups. One-year to six-year progression-free survival rates of the two groups and the median progression-free survival (mPFS), median overall survival (mOS) of the two groups before and after PSM were calculated respectively. Furthermore, 15 factors that may affect the mPFS in CRC were included in COX multivariate regression analysis to explore the prognostic factors related to CRC as well as to analyze the risk ratio of different subgroups. Results. A total of 529 CRC patients were included in our study, 285 patients were in the TCM treatment group and 244 patients were in the control group. Before PSM, the mPFS and mOS in the TCM treatment group were 68 months and 75 months respectively, while mPFS and mOS in the control group were 40 months and 65 months respectively. After PSM, mPFS and mOS in the TCM treatment group were both 75 months, while mPFS and mOS in the control group were 28 months and 44 months respectively. One-year to six-year progression-free survival rates were 94.0%, 76.1%, 64.7%, 57.9%, 52.0%, 44.1% respectively in the TCM treatment group, and 78.6%, 61.4%, 51.7%, 40.8%, 33.0%, 29.1% respectively in the control group (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/7023420