An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study

• Published in: Türk göğüs kalp damar cerrahisi dergisi 2019-10, Vol.27 (4), p.513-520
• Main Authors: Özbudak, Ersan, Eraldemir, Fatma Ceyla, Arıkan, Ali Ahmet, Şahin, Deniz, Maral Kır, Hale, Kurt, Tolga, Gülaştı, Ömer Faruk, Yavuz, Şadan
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1301-5680; 2149-8156
• DOI: 10.5606/tgkdc.dergisi.2019.18061

This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were defined as follows: control (Group 1), sham (Group 2), clopidogrel pre-treatment (Group 3), and rivaroxaban pre-treatment (Group 4). Ischemia (6 h) and reperfusion (8 h) were induced at the lower hind limb in Groups 2, 3, and 4. The ischemic muscle, heart, kidney, liver, and plasma tissues of the subjects were obtained to test for the oxidant (malondialdehyde) and antioxidants (glutathione, superoxide dismutase, and nitric oxide). Malondialdehyde levels were significantly higher in the sham group, compared to the controls in all tissues. Clopidogrel and rivaroxaban pre-treatment significantly decreased malondialdehyde levels, compared to the heart, ischemic muscle, liver, and blood tissues of the sham group. Kidney malondialdehyde levels were reduced only by rivaroxaban. Group 4 had significantly decreased malondialdehyde levels, compared to Group 3 in ischemic muscle (p