Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance

Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 assume and its role in peripheral tolerance remain elusive. We induce CBA-specific, IL-35-producing T regulatory (Treg) cells in T...

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Published in:	Cell reports (Cambridge) 2020-01, Vol.30 (4), p.1039-1051.e5
Main Authors:	Sullivan, Jeremy A., Tomita, Yusuke, Jankowska-Gan, Ewa, Lema, Diego A., Arvedson, Matt P., Nair, Ashita, Bracamonte-Baran, William, Zhou, Ying, Meyer, Kristy K., Zhong, Weixiong, Sawant, Deepali V., Szymczak-Workman, Andrea L., Zhang, Qianxia, Workman, Creg J., Hong, Seungpyo, Vignali, Dario A.A., Burlingham, William J.
Format:	Article
Language:	English
Subjects:	Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD81 Coculture Techniques cytokines Ebi3 exosome extracellular vesicles Extracellular Vesicles - immunology Extracellular Vesicles - metabolism Extracellular Vesicles - ultrastructure Female Forkhead Transcription Factors - metabolism Gene Knockout Techniques Heart Transplantation IL-35 Immune Tolerance Immunosuppression Interleukin-12 Subunit p35 - metabolism Interleukins - immunology Interleukins - metabolism Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Microscopy, Electron, Transmission Minor Histocompatibility Antigens - metabolism p35 Receptors, Cytokine - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism tetraspanin tolerance Treg
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