Association of serum ferritin with metabolic syndrome in eight cities in China

Objective This study aims to evaluate the cross‐sectional association of serum ferritin (SF) and the risk of metabolic syndrome (MetS) and its components among adults in eight cities in China. Methods Subjects were recruited using a combination of systematic cluster random sampling and purposive sam...

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Bibliographic Details
Published in:Food science & nutrition 2020-03, Vol.8 (3), p.1406-1414
Main Authors: Wang, Meichen, Zhao, Ai, Szeto, Ignatius Man‐Yau, Wu, Wei, Ren, Zhongxia, Li, Ting, Feng, Haotian, Wang, Peiyu, Wang, Yan, Zhang, Yumei
Format: Article
Language:English
Subjects:
Age
Alcohol use
Anthropometry
Blood
Blood glucose
Body mass index
Cholesterol
Cities
Diabetes
Diet
Dietary intake
Fasting
Ferritin
Food intake
Gender differences
Glucose
Hypertension
Hypertriglyceridemia
Insulin
Insulin resistance
Laboratories
Men
Metabolic disorders
Metabolic syndrome
Original Research
Population
Random sampling
Regression analysis
serum ferritin
Smoking
Sociodemographics
Standard deviation
Statistical sampling
Studies
Triglycerides
Variables
Women
Womens health
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Summary:Objective This study aims to evaluate the cross‐sectional association of serum ferritin (SF) and the risk of metabolic syndrome (MetS) and its components among adults in eight cities in China. Methods Subjects were recruited using a combination of systematic cluster random sampling and purposive sampling in eight cities in China. The sociodemographic characteristics, data of lifestyle factors, self‐reported disease history, and 24‐hr dietary intake were obtained using a validated questionnaire. Anthropometry was performed, and fasting blood was collected to test the SF, fasting blood glucose (FBG), insulin, high‐sensitivity C‐reactive protein (hs‐CRP), triglycerides (TG), and cholesterols. Logistic and linear regression analyses were conducted to investigate the associations, adjusting for age, city level, smoking, drinking, weekly moderate‐to‐vigorous activity, dietary factors, hs‐CRP, and BMI. Results Serum ferritin level is positively correlated with total cholesterol, TG, FBG, HOMA‐IR, and hs‐CRP after adjusting for age and BMI. The odds ratio (OR) for MetS in the highest quartile of SF was 2.23 (1.32, 3.77) after adjusting for men, compared with the lowest quartile. An elevated ferritin concentration was significantly related to hypertriglyceridemia (p 
ISSN:2048-7177
2048-7177
DOI:10.1002/fsn3.1408