Evolution of the Small Family of Alternative Splicing Modulators Nuclear Speckle RNA-binding Proteins in Plants

RNA-Binding Protein 1 (RBP1) was first identified as a protein partner of the long noncoding RNA (lncRNA) in , involved in symbiotic nodule development. RBP1 is localized in nuclear speckles and can be relocalized to the cytoplasm by the interaction with . The two closest homologs to RBP1 in were ca...

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Bibliographic Details
Published in:Genes 2020-02, Vol.11 (2), p.207
Main Authors: Lucero, Leandro, Bazin, Jeremie, Rodriguez Melo, Johan, Ibañez, Fernando, Crespi, Martín D, Ariel, Federico
Format: Article
Language:English
Subjects:
Alternative Splicing
Cell Nucleus - metabolism
Cytoplasm - metabolism
Embryophyta - genetics
Embryophyta - growth & development
Evolution, Molecular
Gene Expression Regulation, Plant
Genetics
Life Sciences
Lotus - genetics
Lotus - growth & development
Medicago truncatula - genetics
Medicago truncatula - growth & development
Phylogeny
Plant Proteins - genetics
Plant Proteins - metabolism
Plant Roots - genetics
Plant Roots - growth & development
RNA, Long Noncoding - genetics
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
Symbiosis
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Summary:RNA-Binding Protein 1 (RBP1) was first identified as a protein partner of the long noncoding RNA (lncRNA) in , involved in symbiotic nodule development. RBP1 is localized in nuclear speckles and can be relocalized to the cytoplasm by the interaction with . The two closest homologs to RBP1 in were called Nuclear Speckle RNA-binding proteins (NSRs) and characterized as alternative splicing modulators of specific mRNAs. They can recognize in vivo the lncRNA ( ) among other lncRNAs, regulating lateral root formation. Here, we performed a phylogenetic analysis of NSR/RBP proteins tracking the roots of the family to the Embryophytes. Strikingly, eudicots faced a reductive trend of NSR/RBP proteins in comparison with other groups of flowering plants. In and , their expression profile during nodulation and in specific regions of the symbiotic nodule was compared to that of the lncRNA , as well as to changes in alternative splicing. This hinted at distinct and specific roles of each member during nodulation, likely modulating the population of alternatively spliced transcripts. Our results establish the basis to guide future exploration of NSR/RBP function in alternative splicing regulation in different developmental contexts along the plant lineage.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes11020207