Eukaryotic initiation factor 4A (eIF4A) during viral infections

The helicase eIF4A is part of the cellular eIF4F translation initiation complex. The main functions of eIF4A are to remove secondary complex structures within the 5′-untranslated region and to displace proteins attached to mRNA. As intracellular parasites, viruses regulate the processes involved in...

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Bibliographic Details
Published in:Virus genes 2019-06, Vol.55 (3), p.267-273
Main Authors: Montero, Hilda, Pérez-Gil, Gustavo, Sampieri, Clara L.
Format: Article
Language:English
Subjects:
5' Untranslated Regions - genetics
Biomedical and Life Sciences
Biomedicine
Cytomegalovirus
DNA helicase
enzymes
Eukaryotic Initiation Factor-4A - genetics
Gene expression
Humans
Infections
Influenza
Initiation complex
Initiation factor eIF-4A
Medical Microbiology
messenger RNA
mRNA
Parasites
Plant Sciences
Protein Binding - genetics
Protein Biosynthesis
Protein synthesis
Proteins
RNA, Messenger - genetics
Translation initiation
Viral infections
Virology
Virus Diseases - genetics
Virus Diseases - virology
Viruses
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Summary:The helicase eIF4A is part of the cellular eIF4F translation initiation complex. The main functions of eIF4A are to remove secondary complex structures within the 5′-untranslated region and to displace proteins attached to mRNA. As intracellular parasites, viruses regulate the processes involved in protein synthesis, and different mechanisms related to controlling translation factors, such as eIF4A, have been found. The inhibitors of this factor are currently known; these substances could be used in the near future as part of antiviral pharmacological therapies in instances of replication cycles in which eIF4A is required. In this review, the particularities of how some viruses make use of this initiation factor to synthesize their proteins are discussed.
ISSN:0920-8569
1572-994X
DOI:10.1007/s11262-019-01641-7