Intraruminal administration of milk in the calf as a model for ruminal drinking: morphological and enzymatical changes in the jejunal mucosa

In order to develop a calf model for studying the syndrome of ruminal drinking (RD) in veal calves, three dual-fistulated calves were used to test the effect of intraruminal administration of milk replacer on the jejunal mucosa. Biopsies of the proximal jejunal mucosa were taken through a jejunal fi...

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Bibliographic Details
Published in:Veterinary research communications 1990-01, Vol.14 (2), p.129-140
Main Authors: Weeren-Keverling Buisman, A. van (Rijksuniversiteit Utrecht (Netherlands). Faculteit der Diergeneeskunde, Vakgroep Geneeskunde en Voeding van Grote Huisdieren), Mouwen, J.M.V.M, Wensing, T, Breukink, H.J
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - metabolism
Animals
beta-Galactosidase - metabolism
Biopsy
CALVES
Cattle
COMPORTEMENT DE BOISSON
Coronaviridae - isolation & purification
DRINKING HABITS
ENZIMAS
ENZYME
ENZYMES
Feces - microbiology
Food, Formulated
HABITOS EN LA BEBIDA
INTESTIN
Intestinal Mucosa - enzymology
Intestinal Mucosa - pathology
INTESTINES
INTESTINOS
Jejunum - enzymology
Jejunum - pathology
LAIT
LECHE
Male
Microvilli - enzymology
Microvilli - pathology
MILK
Milk - metabolism
MODELE
MODELOS
Models, Biological
Pathology
Pseudomonas aeruginosa - isolation & purification
Rotavirus - isolation & purification
Rumen - anatomy & histology
Rumen - enzymology
Rumen - metabolism
TERNERO
Time Factors
VEAU
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Summary:In order to develop a calf model for studying the syndrome of ruminal drinking (RD) in veal calves, three dual-fistulated calves were used to test the effect of intraruminal administration of milk replacer on the jejunal mucosa. Biopsies of the proximal jejunal mucosa were taken through a jejunal fistula and the mucosal morphology and the activities of two brush border enzymes, lactase and alkaline phosphatase, were determined. Means of villus length and brush border enzyme activities decreased during the period of intraruminal administration of milk. The hyperplastic villus atrophy in this model was similar to that found in chronic RD patients in previous studies. This could not be associated with isolation of pathogenic micro-organisms from the faeces and is probably the consequence of the intraruminal milk feeding procedure itself. Clinical recovery from the signs of RD occurred rapidly after intraruminal administration of milk ceased and was followed by restoration of villus length and brush border enzyme activities 3-4 weeks later.
ISSN:0165-7380
1573-7446
DOI:10.1007/BF00346553