Minimum Infective Dose of the Major Human Respiratory and Enteric Viruses Transmitted Through Food and the Environment

Viruses are a significant cause of morbidity and mortality around the world. Determining the minimum dose of virus particles that can initiate infection, termed the minimum infective dose (MID), is important for the development of risk assessment models in the fields of food and water treatment and...

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Bibliographic Details
Published in:Food and environmental virology 2011-03, Vol.3 (1), p.1-30
Main Authors: Yezli, Saber, Otter, Jonathan A.
Format: Article
Language:English
Subjects:
Antibodies
Biomedical and Life Sciences
Biomedicine
Chemistry/Food Science
Disease transmission
Food
Food Science
Hepatitis
Hepatitis A
Infections
Infectivity
Influenza
Morbidity
Review Paper
Rhinovirus
Risk assessment
Rotavirus
Tissue culture
Virology
Viruses
Water treatment
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Summary:Viruses are a significant cause of morbidity and mortality around the world. Determining the minimum dose of virus particles that can initiate infection, termed the minimum infective dose (MID), is important for the development of risk assessment models in the fields of food and water treatment and the implementation of appropriate infection control strategies in healthcare settings. Both respiratory and enteric viruses can be shed at high titers from infected individuals even when the infection is asymptomatic. Presence of pre-existing antibodies has been shown to affect the infectious dose and to be protective against reinfection for many, but not all viruses. Most respiratory viruses appear to be as infective in humans as in tissue culture. Doses of
ISSN:1867-0334
1867-0342
1867-0342
DOI:10.1007/s12560-011-9056-7