Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit

Objective To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. Study design Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testi...

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Bibliographic Details
Published in:Journal of perinatology 2019-05, Vol.39 (5), p.683-689
Main Authors: Poole, Claudette L., Camins, Bernard C., Prichard, Mark N., Faye-Petersen, Ona, Hutto, Cecelia
Format: Article
Language:English
Subjects:
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Alabama
Antibiotics
Birth
Bronchopulmonary Dysplasia - diagnosis
Cross Infection - diagnosis
Cross Infection - virology
Dysplasia
Female
Gestational Age
Health risk assessment
Hospitalization
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infants
Infections
Intensive care
Intensive Care Units, Neonatal
Male
Medicine
Medicine & Public Health
Neonatal care
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Polymerase Chain Reaction
Prospective Studies
Respiratory tract infection
Respiratory Tract Infections - diagnosis
Respiratory Tract Infections - virology
Virus Diseases - diagnosis
Viruses
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Summary:Objective To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. Study design Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. Results Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1.3/1000 patient days). VRI positive infants had a younger gestational age (median 27 w vs. 32 w, p  = 0.048); were hospitalized longer (97 d vs 43 d, p  = 0.013); required more antibiotics (8 d vs. 4 d, p  = 0.037) and were more likely to be diagnosed with bronchopulmonary dysplasia ( p  = 0.008) compared to VRI negative infants. Conclusion Respiratory viruses are a frequent cause of HAI in the NICU and are associated with negative outcomes.
ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-019-0318-9