Engineered cartilage utilizing fetal cartilage-derived progenitor cells for cartilage repair

The aim of this study was to develop a fetal cartilage-derived progenitor cell (FCPC) based cartilage gel through self-assembly for cartilage repair surgery, with clinically useful properties including adhesiveness, plasticity, and continued chondrogenic remodeling after transplantation. Characteriz...

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Bibliographic Details
Published in:Scientific reports 2020-03, Vol.10 (1), p.5722-5722, Article 5722
Main Authors: Park, Do Young, Min, Byoung-Hyun, Park, So Ra, Oh, Hyun Ju, Truong, Minh-Dung, Kim, Mijin, Choi, Ja-Young, Park, In-Su, Choi, Byung Hyune
Format: Article
Language:English
Subjects:
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Alginates
Alginic acid
Animals
Cartilage
Cartilage, Articular - cytology
Cartilage, Articular - transplantation
Chondrocytes - cytology
Chondrocytes - transplantation
Chondrogenesis - physiology
Fetal Stem Cells - cytology
Fetal Stem Cells - transplantation
Fetuses
Gels
Humanities and Social Sciences
Humans
Macaca fascicularis
Male
Mice
multidisciplinary
Progenitor cells
Science
Science (multidisciplinary)
Self-assembly
Stem Cell Transplantation
Stem cells
Surgery
Tissue Engineering - methods
Transplantation
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Summary:The aim of this study was to develop a fetal cartilage-derived progenitor cell (FCPC) based cartilage gel through self-assembly for cartilage repair surgery, with clinically useful properties including adhesiveness, plasticity, and continued chondrogenic remodeling after transplantation. Characterization of the gels according to in vitro self-assembly period resulted in increased chondrogenic features over time. Adhesion strength of the cartilage gels were significantly higher compared to alginate gel, with the 2-wk group showing a near 20-fold higher strength (1.8 ± 0.15 kPa vs. 0.09 ± 0.01 kPa, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-62580-0