Salusin-β is superior to salusin-α as a marker for evaluating coronary atherosclerosis

• Published in: Journal of international medical research 2020-02, Vol.48 (2), p.300060520903868-300060520903868
• Main Authors: Wang, Yuxue, Wang, Songjiao, Zhang, Jun, Zhang, Maona, Zhang, Hong, Gong, Guofu, Luo, Min, Wang, Teng, Mao, Xiaolu
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alternative Splicing; Atherosclerosis; Biomarkers - blood; Chest Pain - blood; Chest Pain - diagnosis; Chest Pain - etiology; Coronary Angiography; Coronary Stenosis - blood; Coronary Stenosis - complications; Coronary Stenosis - diagnosis; Coronary vessels; Electrocardiography; Female; Health risk assessment; Humans; Intercellular Signaling Peptides and Proteins - blood; Male; Middle Aged; Protein Isoforms - blood; Retrospective Clinical Research Report; Retrospective Studies; Severity of Illness Index; Stents
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060520903868

Objective This study was performed to evaluate the interaction effect of salusin-α and salusin-β on coronary artery injury or stenosis. Methods The salusin-α and salusin-β concentrations were measured by enzyme-linked immunosorbent assay in 256 patients who underwent coronary angiography for chest pain, and coronary artery stenosis was assessed by the SYNTAX scoring system. Multivariate logistic regression was used to analyze the correlation between variables and coronary artery stenosis. The interaction of salusin-α and salusin-β on coronary artery stenosis was further explored by multiple linear regression. Results The model goodness of fit (R) for the interaction effect of salusin-α and salusin-β on coronary artery stenosis was 0.863, and the adjusted R value revealed that the interaction could explain 74.3% of the variation in SYNTAX scores. The F-statistic exceeded F0.05 (3.031485935) and P