Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in spike 1 domain and membrane protein of feline infectious peritonitis virus

Highlights • FIPV, belongs to Alphacoronavirus , causes a fatal disease in wild and domestic cats. • Th1 activity plays an important role in protect against FIPV infection. • We identified the Th1 and antibody-binding epitopes in S1 domain and M protein of FIPV. • We selected 3 peptides that strongl...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2014-04, Vol.32 (16), p.1834-1840
Main Authors: Takano, Tomomi, Morioka, Hiroyuki, Gomi, Kohji, Tomizawa, Keisuke, Doki, Tomoyoshi, Hohdatsu, Tsutomu
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Allergy and Immunology
Amino Acid Sequence
Amino acids
Animals
Applied microbiology
Binding Sites, Antibody
Biological and medical sciences
Cats
CD4-positive T-lymphocytes
Coronavirus
Coronavirus, Feline - immunology
Domestic animals
epitopes
Feline coronavirus
Feline infectious peritonitis
Feline infectious peritonitis virus
Female
Fundamental and applied biological sciences. Psychology
Immunodominant Epitopes - immunology
Infections
Liposomes - administration & dosage
Liposomes - immunology
Male
membrane proteins
Microbiology
Miscellaneous
Molecular Sequence Data
Oligodeoxyribonucleotides - administration & dosage
Oligodeoxyribonucleotides - immunology
Peptide-based vaccine
Peptides
Proteins
screening
serotypes
Spike Glycoprotein, Coronavirus - immunology
structural proteins
synthetic peptides
Th1
Th1 Cells - immunology
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Subunit - immunology
Viral Matrix Proteins - immunology
Virology
viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • FIPV, belongs to Alphacoronavirus , causes a fatal disease in wild and domestic cats. • Th1 activity plays an important role in protect against FIPV infection. • We identified the Th1 and antibody-binding epitopes in S1 domain and M protein of FIPV. • We selected 3 peptides that strongly induced Th1 activity from FIPV structural proteins. • 3 peptides were administered with CpG-ODNs to SPF cats, 2 peptides induced Th1 activity.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.01.074