Pituitary-dependent hyperadrenocorticism and generalised toxoplasmosis in a cat with neurological signs

A 12-year-old female neutered cat presented with acute onset unilateral vestibular syndrome, a spontaneous cutaneous wound, polyuria, polydipsia, and diabetes mellitus. Hyperadrenocorticism was demonstrated by means of hyper-responsiveness to adrenocorticotropic hormone stimulation, elevated urine c...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2010-08, Vol.12 (8), p.654-658
Main Authors: Spada, Eva, Proverbio, Daniela, Giudice, Chiara, DiGiancamillo, Mauro, Lodi, Matteo, Perego, Roberta
Format: Article
Language:English
Subjects:
adenoma
adrenal glands
Adrenocortical Hyperfunction - complications
Adrenocortical Hyperfunction - diagnosis
Adrenocortical Hyperfunction - veterinary
Animals
case studies
cat diseases
Cat Diseases - diagnosis
Cats
central vestibular syndrome
clinical examination
computed tomography
corticotropin
cortisol
creatinine
disease course
Euthanasia, Animal
Female
histology
histopathology
hyperadrenocorticism
necropsy
pituitary gland
Pituitary Gland - physiopathology
Pituitary Neoplasms - complications
Pituitary Neoplasms - diagnosis
Pituitary Neoplasms - veterinary
signs and symptoms (animals and humans)
Toxoplasma gondii
toxoplasmosis
Toxoplasmosis, Animal - complications
Toxoplasmosis, Animal - diagnosis
urine
Vestibular Diseases - complications
Vestibular Diseases - veterinary
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Summary:A 12-year-old female neutered cat presented with acute onset unilateral vestibular syndrome, a spontaneous cutaneous wound, polyuria, polydipsia, and diabetes mellitus. Hyperadrenocorticism was demonstrated by means of hyper-responsiveness to adrenocorticotropic hormone stimulation, elevated urine cortisol-to-creatinine ratio, bilaterally enlarged adrenal glands on abdominal ultrasound, and pituitary enlargement on computed tomography imaging. The cat was euthanased and post-mortem histological examination revealed feline skin fragility syndrome; confirmed a pituitary cromophobe macroadenoma; and generalised toxoplasmosis with tachyzoites in the pancreas, bowel and brain. This report is the first to describe the concurrence of macroadenoma pituitary-dependent hyperadrenocorticism and generalised toxoplasmosis in a cat with central vestibular syndrome.
ISSN:1098-612X
1532-2750
DOI:10.1016/j.jfms.2010.01.014