Association of bovine respiratory disease with clinical status and acute phase proteins in calves

• Published in: Comparative Immunology, Microbiology and Infectious Diseases Microbiology and Infectious Diseases, 2007-05, Vol.30 (3), p.143-151
• Main Authors: Nikunen, S, Härtel, H, Orro, T, Neuvonen, E, Tanskanen, R, Kivelä, S.-L, Sankari, S, Aho, P, Pyörälä, S, Saloniemi, H, Soveri, T
• Format: Article
• Language: English
• Subjects: Acute phase proteins; Acute-Phase Proteins - metabolism; Allergy and Immunology; Animals; Bacteriology; Biological and medical sciences; Bovine coronavirus; Bovine respiratory disease; Bovine respiratory syncytial virus; Calf; Cattle; Cattle Diseases - blood; Cattle Diseases - microbiology; Cattle Diseases - virology; Finland; Fundamental and applied biological sciences. Psychology; Infectious Disease; Leukocyte Count; Maladie respiratoire bovine; Microbiology; Miscellaneous; Mycoplasma; Pasteurella Infections - blood; Pasteurella Infections - microbiology; Pasteurella Infections - veterinary; Pasteurella multocida; Pasteurella multocida - isolation & purification; Protéines de phase aiguë; Respiratory Tract Infections - blood; Respiratory Tract Infections - microbiology; Respiratory Tract Infections - veterinary; Respiratory Tract Infections - virology; Veau; Virology; Virus
• ISSN: 0147-9571; 1878-1667; 1365-2567
• DOI: 10.1016/j.cimid.2006.11.004

Abstract Eighty-four calves with respiratory disease from 18 herds in different parts of Finland were chosen for a study evaluating the capacity of different respiratory pathogens to cause changes in different acute phase protein concentrations, white blood cell (WBC) count and clinical signs. The selected acute phase proteins were fibrinogen, haptoglobin, serum amyloid-A, lipopolysaccharide binding protein and α 1-acid glycoprotein. From each calf, a paired blood sample was obtained for serological studies of bovine parainfluenza virus-3, bovine respiratory syncytial virus, bovine coronavirus, bovine adenovirus-3 and bovine adenovirus-7. Tracheobronchial lavage was performed to detect bacteria and mycoplasma. Isolation of Pasteurella multocida was associated with increased concentrations of all tested acute phase proteins. For other pathogens, no significant relationships were observed. No association was present between viral or bacterial findings and WBC count.