Impact of overweightness and critical weight loss on overall survival in patients with hepatocellular carcinoma initially treated with chemoembolization

BackgroundThe effects of overweightness and weight loss on the development and prognosis of hepatocellular carcinoma (HCC) remain unclear. In this study, we aimed to evaluate the impact of overweightness and weight loss on the survival of patients with intermediate/advanced HCC receiving chemoemboli...

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Published in:Gastroenterology report 2020-04, Vol.8 (2), p.125-133
Main Authors: Chen, Zhen-Xin, Jian, Zhi-Wei, Wu, Xi-Wen, Wang, Jun-Cheng, Peng, Jing-Yuan, Huang, Chun-Yu, Lao, Xiang-Ming
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Language:English
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Summary:BackgroundThe effects of overweightness and weight loss on the development and prognosis of hepatocellular carcinoma (HCC) remain unclear. In this study, we aimed to evaluate the impact of overweightness and weight loss on the survival of patients with intermediate/advanced HCC receiving chemoembolization as initial treatment.MethodsWe examined 1,170 patients who underwent chemoembolization as initial treatment for Barcelona-Clínic Liver Cancer stages B and C HCC at Sun Yat-sen University Cancer Center (Guangzhou, China) between December 2009 and May 2015. A baseline body mass index (BMI) of ≥23 kg/m2 was defined as overweight, and body-weight loss of ≥5.0% from baseline was defined as critical weight loss (CWL). Cox regression analysis was used to determine the association between overweightness or CWL and overall survival (OS).ResultsThe median survival time was 16.8 (95% confidence interval, 13.9–19.7) months and 11.1 (95% confidence interval, 10.0–12.2) months in the overweight and non-overweight groups (log-rank test, P 
ISSN:2052-0034
2052-0034
DOI:10.1093/gastro/goz040