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Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus
Abstract Background Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HS...
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Published in: | Clinical infectious diseases 2020-04, Vol.70 (8), p.1701-1707 |
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creator | Stier, Elizabeth A Lensing, Shelly Y Darragh, Teresa M Deshmukh, Ashish A Einstein, Mark H Palefsky, Joel M Jay, Naomi Berry-Lawhorn, J Michael Wilkin, Timothy Wiley, Dorothy J Barroso, Luis F Cranston, Ross D Levine, Rebecca Guiot, Humberto M French, Audrey L Citron, Deborah Rezaei, M Katayoon Goldstone, Stephen E Chiao, Elizabeth |
description | Abstract
Background
Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HSIL prevalence among WLHIV in the United States are lacking.
Methods
The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate the prevalence of and risk factors for anal HSIL in a US cohort. Eligible participants were WLHIV aged ≥18 years with no history of anal HSIL. Study participants had an examination including collection of cervical/vaginal and anal specimens, followed by high-resolution anoscopy with biopsy.
Results
We enrolled 256 women with evaluable anal pathology. The mean age was 49.4 years, 64% women were non-Hispanic black, 67% were former or current smokers, and 56% reported ever having anal sex with a man. The median CD4 T-cell count was 664 cells/μL. The prevalence of anal histologic HSIL (hHSIL) was 27% (95% confidence interval [CI], 22%–33%). There was a strong concordance (240/254) between local and consensus pathologists for hHSIL vs less than hHSIL (κ = 0.86 [95% CI, .79–.93]). Current CD4 count of ≤200 cells/μL was the strongest predictor of consensus anal hHSIL diagnosis (adjusted odds ratio [aOR], 10.34 [95% CI, 3.47–30.87]). History of anoreceptive intercourse was also associated with hHSIL (aOR, 2.44 [95% CI, 1.22–4.76]).
Conclusions
The prevalence of anal hHSIL in WLHIV in the United States was 27% in this study where all participants received high-resolution anoscopy and biopsy.
To determine the true prevalence of anal high-grade squamous intraepithelial lesions in women living with human immunodeficiency virus in the United States, we conducted high-resolution anoscopy and biopsies on all participants in the study. The prevalence was 27%, and substantially higher than previous reports. |
doi_str_mv | 10.1093/cid/ciz408 |
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Background
Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HSIL prevalence among WLHIV in the United States are lacking.
Methods
The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate the prevalence of and risk factors for anal HSIL in a US cohort. Eligible participants were WLHIV aged ≥18 years with no history of anal HSIL. Study participants had an examination including collection of cervical/vaginal and anal specimens, followed by high-resolution anoscopy with biopsy.
Results
We enrolled 256 women with evaluable anal pathology. The mean age was 49.4 years, 64% women were non-Hispanic black, 67% were former or current smokers, and 56% reported ever having anal sex with a man. The median CD4 T-cell count was 664 cells/μL. The prevalence of anal histologic HSIL (hHSIL) was 27% (95% confidence interval [CI], 22%–33%). There was a strong concordance (240/254) between local and consensus pathologists for hHSIL vs less than hHSIL (κ = 0.86 [95% CI, .79–.93]). Current CD4 count of ≤200 cells/μL was the strongest predictor of consensus anal hHSIL diagnosis (adjusted odds ratio [aOR], 10.34 [95% CI, 3.47–30.87]). History of anoreceptive intercourse was also associated with hHSIL (aOR, 2.44 [95% CI, 1.22–4.76]).
Conclusions
The prevalence of anal hHSIL in WLHIV in the United States was 27% in this study where all participants received high-resolution anoscopy and biopsy.
To determine the true prevalence of anal high-grade squamous intraepithelial lesions in women living with human immunodeficiency virus in the United States, we conducted high-resolution anoscopy and biopsies on all participants in the study. The prevalence was 27%, and substantially higher than previous reports.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciz408</identifier><identifier>PMID: 31292602</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Anal Canal ; and Commentaries ; Anus Neoplasms - epidemiology ; Female ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; Humans ; Male ; Middle Aged ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Prevalence ; Risk Factors ; Squamous Intraepithelial Lesions</subject><ispartof>Clinical infectious diseases, 2020-04, Vol.70 (8), p.1701-1707</ispartof><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-24b2a98e7fa514efa0c446a1db8b3e57716c2237ebbb1705690cecabe3dbb7293</citedby><cites>FETCH-LOGICAL-c408t-24b2a98e7fa514efa0c446a1db8b3e57716c2237ebbb1705690cecabe3dbb7293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31292602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stier, Elizabeth A</creatorcontrib><creatorcontrib>Lensing, Shelly Y</creatorcontrib><creatorcontrib>Darragh, Teresa M</creatorcontrib><creatorcontrib>Deshmukh, Ashish A</creatorcontrib><creatorcontrib>Einstein, Mark H</creatorcontrib><creatorcontrib>Palefsky, Joel M</creatorcontrib><creatorcontrib>Jay, Naomi</creatorcontrib><creatorcontrib>Berry-Lawhorn, J Michael</creatorcontrib><creatorcontrib>Wilkin, Timothy</creatorcontrib><creatorcontrib>Wiley, Dorothy J</creatorcontrib><creatorcontrib>Barroso, Luis F</creatorcontrib><creatorcontrib>Cranston, Ross D</creatorcontrib><creatorcontrib>Levine, Rebecca</creatorcontrib><creatorcontrib>Guiot, Humberto M</creatorcontrib><creatorcontrib>French, Audrey L</creatorcontrib><creatorcontrib>Citron, Deborah</creatorcontrib><creatorcontrib>Rezaei, M Katayoon</creatorcontrib><creatorcontrib>Goldstone, Stephen E</creatorcontrib><creatorcontrib>Chiao, Elizabeth</creatorcontrib><title>Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Background
Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HSIL prevalence among WLHIV in the United States are lacking.
Methods
The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate the prevalence of and risk factors for anal HSIL in a US cohort. Eligible participants were WLHIV aged ≥18 years with no history of anal HSIL. Study participants had an examination including collection of cervical/vaginal and anal specimens, followed by high-resolution anoscopy with biopsy.
Results
We enrolled 256 women with evaluable anal pathology. The mean age was 49.4 years, 64% women were non-Hispanic black, 67% were former or current smokers, and 56% reported ever having anal sex with a man. The median CD4 T-cell count was 664 cells/μL. The prevalence of anal histologic HSIL (hHSIL) was 27% (95% confidence interval [CI], 22%–33%). There was a strong concordance (240/254) between local and consensus pathologists for hHSIL vs less than hHSIL (κ = 0.86 [95% CI, .79–.93]). Current CD4 count of ≤200 cells/μL was the strongest predictor of consensus anal hHSIL diagnosis (adjusted odds ratio [aOR], 10.34 [95% CI, 3.47–30.87]). History of anoreceptive intercourse was also associated with hHSIL (aOR, 2.44 [95% CI, 1.22–4.76]).
Conclusions
The prevalence of anal hHSIL in WLHIV in the United States was 27% in this study where all participants received high-resolution anoscopy and biopsy.
To determine the true prevalence of anal high-grade squamous intraepithelial lesions in women living with human immunodeficiency virus in the United States, we conducted high-resolution anoscopy and biopsies on all participants in the study. The prevalence was 27%, and substantially higher than previous reports.</description><subject>Anal Canal</subject><subject>and Commentaries</subject><subject>Anus Neoplasms - epidemiology</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Squamous Intraepithelial Lesions</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUtr3DAQx0VpaV699AMUXQoh4FSSH7IvhRCS7sJCQ_M6ipE83lVrSxvJ3pDc-72jsGloLz0MMzA__vP4E_KRs2POmvyLsW2Kx4LVb8guL3OZVWXD36aalXVW1Hm9Q_Zi_MkY5zUr35OdnItGVEzskt8XATfQozNIfUfBtfSHjb_oOZjRh0g7H-iJg57O7HKVLQO0SC_vJhj8FOncjQFwbccV9jYxC4zWu0ito7d-QEcXdmPdkt4ngs6mARydD8PkfIudNTYNfaA3NkzxgLzroI_44SXvk-vzs6vTWbb4_m1-erLITDpuzEShBTQ1yg5KXmAHzBRFBbzVtc6xlJJXRohcotaaS1ZWDTNoQGPeai1Fk--Tr1vd9aQHbA0-H9CrdbADhAflwap_O86u1NJvlORFxRhLAocvAsHfTRhHNdhosO_BYfqIEqKsOJNNIRN6tEVN8DEG7F7HcKaefVPJN7X1LcGf_l7sFf1jVAI-bwE_rf8n9AS8GaSt</recordid><startdate>20200410</startdate><enddate>20200410</enddate><creator>Stier, Elizabeth A</creator><creator>Lensing, Shelly Y</creator><creator>Darragh, Teresa M</creator><creator>Deshmukh, Ashish A</creator><creator>Einstein, Mark H</creator><creator>Palefsky, Joel M</creator><creator>Jay, Naomi</creator><creator>Berry-Lawhorn, J Michael</creator><creator>Wilkin, Timothy</creator><creator>Wiley, Dorothy J</creator><creator>Barroso, Luis F</creator><creator>Cranston, Ross D</creator><creator>Levine, Rebecca</creator><creator>Guiot, Humberto M</creator><creator>French, Audrey L</creator><creator>Citron, Deborah</creator><creator>Rezaei, M Katayoon</creator><creator>Goldstone, Stephen E</creator><creator>Chiao, Elizabeth</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200410</creationdate><title>Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus</title><author>Stier, Elizabeth A ; Lensing, Shelly Y ; Darragh, Teresa M ; Deshmukh, Ashish A ; Einstein, Mark H ; Palefsky, Joel M ; Jay, Naomi ; Berry-Lawhorn, J Michael ; Wilkin, Timothy ; Wiley, Dorothy J ; Barroso, Luis F ; Cranston, Ross D ; Levine, Rebecca ; Guiot, Humberto M ; French, Audrey L ; Citron, Deborah ; Rezaei, M Katayoon ; Goldstone, Stephen E ; Chiao, Elizabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-24b2a98e7fa514efa0c446a1db8b3e57716c2237ebbb1705690cecabe3dbb7293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anal Canal</topic><topic>and Commentaries</topic><topic>Anus Neoplasms - epidemiology</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Squamous Intraepithelial Lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stier, Elizabeth A</creatorcontrib><creatorcontrib>Lensing, Shelly Y</creatorcontrib><creatorcontrib>Darragh, Teresa M</creatorcontrib><creatorcontrib>Deshmukh, Ashish A</creatorcontrib><creatorcontrib>Einstein, Mark H</creatorcontrib><creatorcontrib>Palefsky, Joel M</creatorcontrib><creatorcontrib>Jay, Naomi</creatorcontrib><creatorcontrib>Berry-Lawhorn, J Michael</creatorcontrib><creatorcontrib>Wilkin, Timothy</creatorcontrib><creatorcontrib>Wiley, Dorothy J</creatorcontrib><creatorcontrib>Barroso, Luis F</creatorcontrib><creatorcontrib>Cranston, Ross D</creatorcontrib><creatorcontrib>Levine, Rebecca</creatorcontrib><creatorcontrib>Guiot, Humberto M</creatorcontrib><creatorcontrib>French, Audrey L</creatorcontrib><creatorcontrib>Citron, Deborah</creatorcontrib><creatorcontrib>Rezaei, M Katayoon</creatorcontrib><creatorcontrib>Goldstone, Stephen E</creatorcontrib><creatorcontrib>Chiao, Elizabeth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stier, Elizabeth A</au><au>Lensing, Shelly Y</au><au>Darragh, Teresa M</au><au>Deshmukh, Ashish A</au><au>Einstein, Mark H</au><au>Palefsky, Joel M</au><au>Jay, Naomi</au><au>Berry-Lawhorn, J Michael</au><au>Wilkin, Timothy</au><au>Wiley, Dorothy J</au><au>Barroso, Luis F</au><au>Cranston, Ross D</au><au>Levine, Rebecca</au><au>Guiot, Humberto M</au><au>French, Audrey L</au><au>Citron, Deborah</au><au>Rezaei, M Katayoon</au><au>Goldstone, Stephen E</au><au>Chiao, Elizabeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2020-04-10</date><risdate>2020</risdate><volume>70</volume><issue>8</issue><spage>1701</spage><epage>1707</epage><pages>1701-1707</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Abstract
Background
Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HSIL prevalence among WLHIV in the United States are lacking.
Methods
The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate the prevalence of and risk factors for anal HSIL in a US cohort. Eligible participants were WLHIV aged ≥18 years with no history of anal HSIL. Study participants had an examination including collection of cervical/vaginal and anal specimens, followed by high-resolution anoscopy with biopsy.
Results
We enrolled 256 women with evaluable anal pathology. The mean age was 49.4 years, 64% women were non-Hispanic black, 67% were former or current smokers, and 56% reported ever having anal sex with a man. The median CD4 T-cell count was 664 cells/μL. The prevalence of anal histologic HSIL (hHSIL) was 27% (95% confidence interval [CI], 22%–33%). There was a strong concordance (240/254) between local and consensus pathologists for hHSIL vs less than hHSIL (κ = 0.86 [95% CI, .79–.93]). Current CD4 count of ≤200 cells/μL was the strongest predictor of consensus anal hHSIL diagnosis (adjusted odds ratio [aOR], 10.34 [95% CI, 3.47–30.87]). History of anoreceptive intercourse was also associated with hHSIL (aOR, 2.44 [95% CI, 1.22–4.76]).
Conclusions
The prevalence of anal hHSIL in WLHIV in the United States was 27% in this study where all participants received high-resolution anoscopy and biopsy.
To determine the true prevalence of anal high-grade squamous intraepithelial lesions in women living with human immunodeficiency virus in the United States, we conducted high-resolution anoscopy and biopsies on all participants in the study. The prevalence was 27%, and substantially higher than previous reports.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31292602</pmid><doi>10.1093/cid/ciz408</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anal Canal and Commentaries Anus Neoplasms - epidemiology Female HIV HIV Infections - complications HIV Infections - epidemiology Humans Male Middle Aged Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Prevalence Risk Factors Squamous Intraepithelial Lesions |
title | Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus |
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