Menstrual and obstetrical bleeding in women with inherited platelet receptor defects—A systematic review

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia 2020-03, Vol.26 (2), p.216-227
• Main Authors: Punt, Marieke C., Schuitema, Pauline C. E., Bloemenkamp, Kitty W. M., Kremer Hovinga, Idske C. L., Galen, Karin P. M.
• Format: Article
• Language: English
• Subjects: Alloantibodies; Bernard-Soulier syndrome; Bleeding; Blood Platelets - pathology; Case reports; Female; Glanzmann thrombasthenia; gynaecological bleeding; heavy menstrual bleeding; Hematological diseases; Hemorrhage; Histocompatibility antigen HLA; Humans; inherited platelet receptor defects; Menorrhagia - etiology; Menstruation; Neonates; obstetrical bleeding; Platelets; Postpartum; postpartum haemorrhage; Postpartum Hemorrhage - etiology; Prophylaxis; Review
• ISSN: 1351-8216; 1365-2516; 1365-2516
• DOI: 10.1111/hae.13927

Introduction Women with inherited platelet receptor defects (IPRD) may have an increased risk of heavy menstrual bleeding (HMB) and postpartum haemorrhage (PPH). Aim To present a systematic overview of the literature on the prevalence and management of menstrual and obstetrical bleeding in women with IPRD. Methods Electronic databases were searched for original patient data on the prevalence and management of HMB and PPH in women with known IPRD or who were being investigated for IPRD. Results Sixty‐nine papers (61 case reports/series and 8 cohort studies) were included. Overall, studies were rated as ‘poor quality’. The included cohort studies reported HMB in 25% (13/52) of women with Bernard‐Soulier syndrome and in 22.1% (34/154) of women with Glanzmann thrombasthenia. In total, 164 deliveries in women with IPRD were described. Excessive bleeding occurred in 16.9% (11/65) of deliveries described in the largest cohort. PPH occurred in 63.2% (55/87) of deliveries described in case reports/series. PPH occurred in 73.7% (14/19) of deliveries that were not covered by prophylaxis compared with 54.2% (32/59) of deliveries that were (OR = 2.36, 95% CI 0.75‐7.40). Neonatal bleeding complications were reported in 10.0% (8/80) of deliveries. In all (6/6) deliveries with neonatal bleeding complications wherein the presence of alloantibodies was investigated, either antiplatelet or anti‐HLA antibodies were detected. Discussion/Conclusion Menstrual and particularly obstetrical bleeding problems frequently occur in women with IPRD, based on small case reports and series of poor quality. International collaboration, preferably on prospective studies, is needed to improve clinical management of women‐specific bleeding in IPRD.