Restricting vitamin A intake increases bone formation in Zambian children with high liver stores of vitamin

Summary This analysis was performed in Zambian children who had a high prevalence of hypervitaminosis A, defined as >  1.0 μmol retinol/g liver. Bone parameters included markers of bone formation (P1NP), bone resorption (CTX), parathyroid hormone, calcium, vitamin A, and vitamin D. Low dietary vi...

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Bibliographic Details
Published in:Archives of osteoporosis 2019-06, Vol.14 (1), p.72-72, Article 72
Main Authors: Tanumihardjo, S. A., Gannon, B. M., Kaliwile, C., Chileshe, J., Binkley, N. C.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Bone Remodeling
C-Reactive Protein
Child
Child, Preschool
Diet
Diterpenes
Endocrinology
Female
Humans
Hypervitaminosis A - diet therapy
Liver
Male
Medicine
Medicine & Public Health
Nutritional Status
Orthopedics
Osteogenesis
Parathyroid Hormone - blood
Provitamins
Short Communication
Vitamin A - adverse effects
Vitamin A - analogs & derivatives
Vitamins
Zea mays
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Summary:Summary This analysis was performed in Zambian children who had a high prevalence of hypervitaminosis A, defined as >  1.0 μmol retinol/g liver. Bone parameters included markers of bone formation (P1NP), bone resorption (CTX), parathyroid hormone, calcium, vitamin A, and vitamin D. Low dietary vitamin A intake increased P1NP. Purpose Vitamin A (VA) interacts with bone health, but mechanisms require clarification. In countries where multiple interventions exist to eradicate VA deficiency, some groups are consuming excessive VA. Bone metabolism and inflammatory parameters were measured in Zambian children who had high prevalence of hypervitaminosis A determined by 13 C-retinol isotope dilution. Methods Children ( n  = 143), 5 to 7 years, were recruited into a placebo-controlled biofortified orange maize feeding study for 90 days. Bone turnover (P1NP and CTX) and inflammatory (C-reactive protein (CRP) and alpha-1-acid glycoprotein) biomarkers were measured in fasting blood samples before and/or after intervention with the following: (1) VA at the recommended dietary allowance (400 μg retinol activity equivalents/day (as retinyl palmitate)), (2) maize enhanced with the provitamin A carotenoid β-carotene (2.86 mg/day), or (3) a placebo. Parathyroid hormone, calcium, and 25(OH)-vitamin D were measured at end line. Results Bone formation, as measured by P1NP, increased ( P  
ISSN:1862-3522
1862-3514
DOI:10.1007/s11657-019-0617-y