The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection

Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophage...

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Bibliographic Details
Published in:Disease markers 2020, Vol.2020 (2020), p.1-7
Main Authors: Wang, Sheng, Jiang, Hui-fen, Wu, Jun-zhou, Song, Qian, Cai, Shu-nv
Format: Article
Language:English
Subjects:
Age
Biomarkers
Biomarkers, Tumor - blood
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Chemotherapy
Clinical outcomes
Esophageal cancer
Esophageal Neoplasms - blood
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophagus
Female
Humans
Inflammation
Leukocyte Count
Lung cancer
Lymphatic system
Lymphocytes
Lymphocytes - pathology
Male
Medical prognosis
Medical research
Medicine, Experimental
Metastasis
Middle Aged
Monocytes
Monocytes - pathology
Multivariate analysis
Neutrophils
Pathology
Patient outcomes
Patients
Prognosis
Radiation therapy
Software
Squamous cell carcinoma
Statistical analysis
Surgery
Survival
Treatment Outcome
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Summary:Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC), but the clinical value of the LMRc remains unknown. Methods. 674 patients in ESCC undergoing curative operation were enrolled in this study. LMRc (LMRc=pre‐LMR–post‐LMR) was counted on the basis of data within one week before and after operation. The median of LMRc was chosen to be the optimal cut-off value to evaluate the prognostic value of LMRc. Results. Kaplan-Meier curves revealed that LMRc≤1.59 was significantly associated with worse overall survival (OS) (P=0.003) and disease-free survival (DFS) (P=0.008). Multivariate analysis suggested that LMRc could serve as an independent prognostic predictor for both OS (P=0.006, HR=0.687, 95% CI 0.526-0.898) and DFS (P=0.003, HR=0.640, 95% CI 0.476-0.859). Conclusions. LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation.
ISSN:0278-0240
1875-8630
DOI:10.1155/2020/1451864