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The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection
Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophage...
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Published in: | Disease markers 2020, Vol.2020 (2020), p.1-7 |
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description | Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC), but the clinical value of the LMRc remains unknown. Methods. 674 patients in ESCC undergoing curative operation were enrolled in this study. LMRc (LMRc=pre‐LMR–post‐LMR) was counted on the basis of data within one week before and after operation. The median of LMRc was chosen to be the optimal cut-off value to evaluate the prognostic value of LMRc. Results. Kaplan-Meier curves revealed that LMRc≤1.59 was significantly associated with worse overall survival (OS) (P=0.003) and disease-free survival (DFS) (P=0.008). Multivariate analysis suggested that LMRc could serve as an independent prognostic predictor for both OS (P=0.006, HR=0.687, 95% CI 0.526-0.898) and DFS (P=0.003, HR=0.640, 95% CI 0.476-0.859). Conclusions. LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation. |
doi_str_mv | 10.1155/2020/1451864 |
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fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7193282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A627689523</galeid><sourcerecordid>A627689523</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-d7fedf1e773d3aca782f5c815f0c3d03ab3ef394cbbaaaeb989e1535c2d743853</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhxhlZ4oIES_0Rx_YFqYrKh7SoVWnPlteZJK4Se2snrfYP8TvxapdSOHGypXnmnXlHb1G8JvgjIZyfUEzxCSk5kVX5pFgQKfhSVgw_LRaYCrnEtMRHxYuUbjAmVJXqeXHEKBOCVnJR_LzqAV2ENIUNRDO5O0Cr7bjpg91OgKaAvge__1_makB1b3yXOyI0zk4pt4aI6sF5Z82AzufJhhGQ8-gi4-Azce-mHp2lsOlNB5n5cTubMcwJ1TAMqDbROh9Gg659A7ELzneong-rXEICm8f6l8Wz1gwJXh3e4-L689lV_XW5Ov_yrT5dLW2p1LRsRAtNS0AI1jBjjZC05VYS3mLLGszMmkHLVGnXa2MMrJVUQDjjljaiZJKz4-LTXnczr0dobHYQzaA30Y0mbnUwTv9d8a7XXbjTgihGJc0C7w4CMdzOkCY9umSzU-Mhm9aUKSXLshI79O0_6E2Yo8_2dpQoheL4EdWZAbTzbchz7U5Un1ZUVFJxyjL1YU_ZGFKK0D6sTLDexUTvYqIPMcn4m8c2H-DfucjA-z3QO9-Ye_efcpAZaM0fOh9XcMF-AdfU0l4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2397479502</pqid></control><display><type>article</type><title>The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection</title><source>Wiley Online Library Open Access</source><creator>Wang, Sheng ; Jiang, Hui-fen ; Wu, Jun-zhou ; Song, Qian ; Cai, Shu-nv</creator><contributor>Ashwood, Paul ; Paul Ashwood</contributor><creatorcontrib>Wang, Sheng ; Jiang, Hui-fen ; Wu, Jun-zhou ; Song, Qian ; Cai, Shu-nv ; Ashwood, Paul ; Paul Ashwood</creatorcontrib><description>Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC), but the clinical value of the LMRc remains unknown. Methods. 674 patients in ESCC undergoing curative operation were enrolled in this study. LMRc (LMRc=pre‐LMR–post‐LMR) was counted on the basis of data within one week before and after operation. The median of LMRc was chosen to be the optimal cut-off value to evaluate the prognostic value of LMRc. Results. Kaplan-Meier curves revealed that LMRc≤1.59 was significantly associated with worse overall survival (OS) (P=0.003) and disease-free survival (DFS) (P=0.008). Multivariate analysis suggested that LMRc could serve as an independent prognostic predictor for both OS (P=0.006, HR=0.687, 95% CI 0.526-0.898) and DFS (P=0.003, HR=0.640, 95% CI 0.476-0.859). Conclusions. LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2020/1451864</identifier><identifier>PMID: 32377268</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Biomarkers ; Biomarkers, Tumor - blood ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Chemotherapy ; Clinical outcomes ; Esophageal cancer ; Esophageal Neoplasms - blood ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagus ; Female ; Humans ; Inflammation ; Leukocyte Count ; Lung cancer ; Lymphatic system ; Lymphocytes ; Lymphocytes - pathology ; Male ; Medical prognosis ; Medical research ; Medicine, Experimental ; Metastasis ; Middle Aged ; Monocytes ; Monocytes - pathology ; Multivariate analysis ; Neutrophils ; Pathology ; Patient outcomes ; Patients ; Prognosis ; Radiation therapy ; Software ; Squamous cell carcinoma ; Statistical analysis ; Surgery ; Survival ; Treatment Outcome</subject><ispartof>Disease markers, 2020, Vol.2020 (2020), p.1-7</ispartof><rights>Copyright © 2020 Qian Song et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Qian Song et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Qian Song et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-d7fedf1e773d3aca782f5c815f0c3d03ab3ef394cbbaaaeb989e1535c2d743853</citedby><cites>FETCH-LOGICAL-c499t-d7fedf1e773d3aca782f5c815f0c3d03ab3ef394cbbaaaeb989e1535c2d743853</cites><orcidid>0000-0002-3059-8897 ; 0000-0002-8115-3230 ; 0000-0003-4892-7537 ; 0000-0001-6575-1743 ; 0000-0002-4684-6744</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32377268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ashwood, Paul</contributor><contributor>Paul Ashwood</contributor><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Jiang, Hui-fen</creatorcontrib><creatorcontrib>Wu, Jun-zhou</creatorcontrib><creatorcontrib>Song, Qian</creatorcontrib><creatorcontrib>Cai, Shu-nv</creatorcontrib><title>The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC), but the clinical value of the LMRc remains unknown. Methods. 674 patients in ESCC undergoing curative operation were enrolled in this study. LMRc (LMRc=pre‐LMR–post‐LMR) was counted on the basis of data within one week before and after operation. The median of LMRc was chosen to be the optimal cut-off value to evaluate the prognostic value of LMRc. Results. Kaplan-Meier curves revealed that LMRc≤1.59 was significantly associated with worse overall survival (OS) (P=0.003) and disease-free survival (DFS) (P=0.008). Multivariate analysis suggested that LMRc could serve as an independent prognostic predictor for both OS (P=0.006, HR=0.687, 95% CI 0.526-0.898) and DFS (P=0.003, HR=0.640, 95% CI 0.476-0.859). Conclusions. LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation.</description><subject>Age</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - blood</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagus</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocyte Count</subject><subject>Lung cancer</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Monocytes - pathology</subject><subject>Multivariate analysis</subject><subject>Neutrophils</subject><subject>Pathology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Software</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Survival</subject><subject>Treatment Outcome</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkk1v1DAQhiMEokvhxhlZ4oIES_0Rx_YFqYrKh7SoVWnPlteZJK4Se2snrfYP8TvxapdSOHGypXnmnXlHb1G8JvgjIZyfUEzxCSk5kVX5pFgQKfhSVgw_LRaYCrnEtMRHxYuUbjAmVJXqeXHEKBOCVnJR_LzqAV2ENIUNRDO5O0Cr7bjpg91OgKaAvge__1_makB1b3yXOyI0zk4pt4aI6sF5Z82AzufJhhGQ8-gi4-Azce-mHp2lsOlNB5n5cTubMcwJ1TAMqDbROh9Gg659A7ELzneong-rXEICm8f6l8Wz1gwJXh3e4-L689lV_XW5Ov_yrT5dLW2p1LRsRAtNS0AI1jBjjZC05VYS3mLLGszMmkHLVGnXa2MMrJVUQDjjljaiZJKz4-LTXnczr0dobHYQzaA30Y0mbnUwTv9d8a7XXbjTgihGJc0C7w4CMdzOkCY9umSzU-Mhm9aUKSXLshI79O0_6E2Yo8_2dpQoheL4EdWZAbTzbchz7U5Un1ZUVFJxyjL1YU_ZGFKK0D6sTLDexUTvYqIPMcn4m8c2H-DfucjA-z3QO9-Ye_efcpAZaM0fOh9XcMF-AdfU0l4</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Wang, Sheng</creator><creator>Jiang, Hui-fen</creator><creator>Wu, Jun-zhou</creator><creator>Song, Qian</creator><creator>Cai, Shu-nv</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3059-8897</orcidid><orcidid>https://orcid.org/0000-0002-8115-3230</orcidid><orcidid>https://orcid.org/0000-0003-4892-7537</orcidid><orcidid>https://orcid.org/0000-0001-6575-1743</orcidid><orcidid>https://orcid.org/0000-0002-4684-6744</orcidid></search><sort><creationdate>2020</creationdate><title>The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection</title><author>Wang, Sheng ; Jiang, Hui-fen ; Wu, Jun-zhou ; Song, Qian ; Cai, Shu-nv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-d7fedf1e773d3aca782f5c815f0c3d03ab3ef394cbbaaaeb989e1535c2d743853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - blood</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagus</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leukocyte Count</topic><topic>Lung cancer</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Monocytes - pathology</topic><topic>Multivariate analysis</topic><topic>Neutrophils</topic><topic>Pathology</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Software</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Survival</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Jiang, Hui-fen</creatorcontrib><creatorcontrib>Wu, Jun-zhou</creatorcontrib><creatorcontrib>Song, Qian</creatorcontrib><creatorcontrib>Cai, Shu-nv</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Sheng</au><au>Jiang, Hui-fen</au><au>Wu, Jun-zhou</au><au>Song, Qian</au><au>Cai, Shu-nv</au><au>Ashwood, Paul</au><au>Paul Ashwood</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC), but the clinical value of the LMRc remains unknown. Methods. 674 patients in ESCC undergoing curative operation were enrolled in this study. LMRc (LMRc=pre‐LMR–post‐LMR) was counted on the basis of data within one week before and after operation. The median of LMRc was chosen to be the optimal cut-off value to evaluate the prognostic value of LMRc. Results. Kaplan-Meier curves revealed that LMRc≤1.59 was significantly associated with worse overall survival (OS) (P=0.003) and disease-free survival (DFS) (P=0.008). Multivariate analysis suggested that LMRc could serve as an independent prognostic predictor for both OS (P=0.006, HR=0.687, 95% CI 0.526-0.898) and DFS (P=0.003, HR=0.640, 95% CI 0.476-0.859). Conclusions. LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32377268</pmid><doi>10.1155/2020/1451864</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3059-8897</orcidid><orcidid>https://orcid.org/0000-0002-8115-3230</orcidid><orcidid>https://orcid.org/0000-0003-4892-7537</orcidid><orcidid>https://orcid.org/0000-0001-6575-1743</orcidid><orcidid>https://orcid.org/0000-0002-4684-6744</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Biomarkers Biomarkers, Tumor - blood Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Chemotherapy Clinical outcomes Esophageal cancer Esophageal Neoplasms - blood Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagus Female Humans Inflammation Leukocyte Count Lung cancer Lymphatic system Lymphocytes Lymphocytes - pathology Male Medical prognosis Medical research Medicine, Experimental Metastasis Middle Aged Monocytes Monocytes - pathology Multivariate analysis Neutrophils Pathology Patient outcomes Patients Prognosis Radiation therapy Software Squamous cell carcinoma Statistical analysis Surgery Survival Treatment Outcome |
title | The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection |
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