Ubiquitin and Receptor-Dependent Mitophagy Pathways and Their Implication in Neurodegeneration

Selective autophagy of mitochondria, or mitophagy, refers to the specific removal and degradation of damaged or surplus mitochondria via targeting to the lysosome for destruction. Disruptions in this homeostatic process may contribute to disease. The identification of diverse mitophagic pathways and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular biology 2020-04, Vol.432 (8), p.2510-2524
Main Authors: Fritsch, Lauren E., Moore, M. Elyse, Sarraf, Shireen A., Pickrell, Alicia M.
Format: Article
Language:English
Subjects:
Animals
Autophagosome
BNIP3L/Nix
Humans
Mitochondria
Mitochondria - metabolism
Mitochondria - pathology
Mitophagy
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
PINK1/Parkin
Protein Kinases - metabolism
Signal Transduction
Ubiquitin
Ubiquitin - metabolism
Ubiquitin-Protein Ligases - metabolism
Ubiquitinated Proteins - metabolism
Ubiquitination
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Selective autophagy of mitochondria, or mitophagy, refers to the specific removal and degradation of damaged or surplus mitochondria via targeting to the lysosome for destruction. Disruptions in this homeostatic process may contribute to disease. The identification of diverse mitophagic pathways and how selectivity for each of these pathways is conferred is just beginning to be understood. The removal of both damaged and healthy mitochondria under disease and physiological conditions is controlled by either ubiquitin-dependent or receptor-dependent mechanisms. In this review, we will discuss the known types of mitophagy observed in mammals, recent findings related to PINK1/Parkin-mediated mitophagy (which is the most well-studied form of mitophagy), the implications of defective mitophagy to neurodegenerative processes, and unanswered questions inspiring future research that would enhance our understanding of mitochondrial quality control. •Mitophagy pathways are either receptor or ubiquitin dependent.•Mitophagy degrades damaged organelles for quality control.•Mitophagy degrades healthy organelles for cellular differentiation.•Defective mitophagy pathways are implicated in neurodegenerative diseases.
ISSN:0022-2836
1089-8638
DOI:10.1016/j.jmb.2019.10.015