Translational impact of NIH-funded nonhuman primate research in transplantation

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune respo...

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Published in:Science translational medicine 2019-07, Vol.11 (500), p.1
Main Authors: Knechtle, Stuart J, Shaw, Julia M, Hering, Bernhard J, Kraemer, Kristy, Madsen, Joren C
Format: Article
Language:English
Subjects:
Animal models
Animals
Chimerism
Clinical trials
Humans
Immune response
Immunologic Memory
Immunotherapy
Islet cells
Lung transplantation
National Institutes of Health (U.S.)
Pancreas transplantation
Pancreatic islet transplantation
Primates
Translational Research, Biomedical
Transplantation
United States
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cited_by cdi_FETCH-LOGICAL-c436t-3ca20edc788a33ee4162d954f47e4e657820a3626a94ab0950255f40b4e5e6403
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container_end_page
container_issue 500
container_start_page 1
container_title Science translational medicine
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creator Knechtle, Stuart J
Shaw, Julia M
Hering, Bernhard J
Kraemer, Kristy
Madsen, Joren C
description The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
doi_str_mv 10.1126/scitranslmed.aau0143
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subjects Animal models
Animals
Chimerism
Clinical trials
Humans
Immune response
Immunologic Memory
Immunotherapy
Islet cells
Lung transplantation
National Institutes of Health (U.S.)
Pancreas transplantation
Pancreatic islet transplantation
Primates
Translational Research, Biomedical
Transplantation
United States
title Translational impact of NIH-funded nonhuman primate research in transplantation
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