Beyond ambulation: Measuring physical activity in youth with Duchenne muscular dystrophy

•In boys with Duchenne muscular dystrophy, accelerometry can measure daily activity.•Accelerometry measures correlate with quantitative muscle testing in boys with DMD.•Accelerometry and quantitative muscle testing showed progressive decline.•The two measures may be complementary to assess skeletal...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2020-04, Vol.30 (4), p.277-282
Main Authors: Killian, Mary, Buchowski, Maciej S., Donnelly, Thomas, Burnette, W. Bryan, Markham, Larry W., Slaughter, James C., Xu, Meng, Crum, Kimberly, Damon, Bruce M., Soslow, Jonathan H.
Format: Article
Language:English
Subjects:
Accelerometry
Adolescent
Child
Duchenne muscular dystrophy
Exercise - physiology
Humans
Male
Muscle Strength - physiology
Muscle, Skeletal - physiopathology
Muscular Dystrophy, Duchenne - physiopathology
Quantitative muscle testing
Skeletal muscle strength
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Summary:•In boys with Duchenne muscular dystrophy, accelerometry can measure daily activity.•Accelerometry measures correlate with quantitative muscle testing in boys with DMD.•Accelerometry and quantitative muscle testing showed progressive decline.•The two measures may be complementary to assess skeletal muscle function in DMD. Patients with Duchenne muscular dystrophy (DMD) develop skeletal muscle weakness and cardiomyopathy. Validated skeletal muscle outcome measures are limited to ambulatory patients, but most DMD patients in cardiac trials are non-ambulatory. New objective functional assessments are needed. This study's objective was to assess the correlation and longitudinal change of two measures: quantitative muscle testing (QMT) and accelerometry. Patients with DMD were prospectively enrolled and underwent QMT and wore wrist and ankle accelerometers for seven days at baseline, 1-, and 2-years. QMT measures were indexed to age. Accelerometer recordings were total vector magnitudes and awake vector magnitude. Correlations were assessed using a Spearman correlation, and longitudinal change was evaluated using a paired t-test or a Wilcoxon signed rank test. Forty-eight participants were included. QMT and accelerometry measures had a moderate or strong correlation, particularly indexed arm QMT with total wrist vector magnitude (rho=0.85, p
ISSN:0960-8966
1873-2364
DOI:10.1016/j.nmd.2020.02.007