The London Chest Activity of Daily Living scale cut-off point to discriminate functional status in patients with chronic obstructive pulmonary disease

• Published in: Revista brasileira de fisioterapia (São Carlos (São Paulo, Brazil)) Brazil)), 2020-05, Vol.24 (3), p.264-272
• Main Authors: Gulart, Aline Almeida, Munari, Anelise Bauer, Klein, Suelen Roberta, Venâncio, Raysa Silva, Alexandre, Hellen Fontão, Mayer, Anamaria Fleig
• Format: Article
• Language: English
• Subjects: Activities of daily living; Body Mass Index; Chronic obstructive pulmonary disease; Dyspnea - physiopathology; Exercise; Forced Expiratory Volume; Humans; Interpretability; London; Lung - physiopathology; Original Research; Outcome assessment (health care); Pulmonary Disease, Chronic Obstructive - physiopathology; Rehabilitation; Spirometry - methods; Surveys and Questionnaires; Thorax - physiopathology; Walk Test - methods
• ISSN: 1413-3555; 1809-9246; 1809-9246
• DOI: 10.1016/j.bjpt.2019.03.002

•The LCADL%total reflected better outcomes for COPD when compared to LCADLtotal.•The 28% cut-off point for LCADL has clinically relevant discriminatory power.•The LCADLtotal may compromise the interpretation of the Pulmonary Rehabilitation Program effects. To determine the cut-off point for the London Chest Activity of Daily Living scale in order to better discriminate functional status. Secondarily, to determine which of the scores (total or %total) is better associated with clinical outcomes of a pulmonary rehabilitation program. Sixty-one patients with chronic obstructive pulmonary disease performed the following tests: spirometry; Chronic Obstructive Pulmonary Disease Assessment Test; Saint George's Respiratory Questionnaire; modified Medical Research Council, the body-mass index, airflow obstruction, dyspnea, and exercise capacity index; six-minute walk test; physical activity in daily life assessment and London Chest Activity of Daily Living scale. Thirty-eight patients were evaluated pre- and post-pulmonary rehabilitation . The cut-off point was determined using the receiver operating characteristic curve with six-minute walk test (cut-off point: 82%pred), modified Medical Research Council (cut-off point: 2), level of physical (in)activity (cut-off point: 80min per day in physical activity ≥3 metabolic equivalent of task) and presence/absence of severe physical inactivity (cut-off point: 4580 steps per day) as anchors. A cut-off point found for all anchors was 28%: modified Medical Research Council [sensitivity=83%; specificity=72%; area under the curve=0.80]; level of physical (in)activity [sensitivity=65%; specificity=59%; area under the curve=0.67] and classification of severe physical inactivity [sensitivity=70%; specificity=62%; area under the curve=0.70]. The patients who scored ≤28% in %total score of London Chest Activity of Daily Living had lower modified Medical Research Council , Chronic Obstructive Pulmonary Disease Assessment Test, Saint George's Respiratory Questionnaire, body-mass index, airflow obstruction, dyspnea and exercise capacity index and sitting time than who scored >28%, and higher forced expiratory volume in the first second, time in physical activity ≥3 metabolic equivalent of task, steps per day and six-minute walk distance. The %total score of London Chest Activity of Daily Living correlated better with clinical outcomes than the total score. The cut-off point of 28% is sensitive and specific to distinguish the function