Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus

Abstract Predatory gastropods of the superfamily Conoidea number over 12,000 living species. The evolutionary success of this lineage can be explained by the ability of conoideans to produce complex venoms for hunting, defense, and competitive interactions. Whereas venoms of cone snails (family Coni...

Full description

Saved in:
Bibliographic Details
Published in:Genome biology and evolution 2020-05, Vol.12 (5), p.684-700
Main Authors: Lu, Aiping, Watkins, Maren, Li, Qing, Robinson, Samuel D, Concepcion, Gisela P, Yandell, Mark, Weng, Zhiping, Olivera, Baldomero M, Safavi-Hemami, Helena, Fedosov, Alexander E
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Conus Snail - genetics
Genetic Variation
Mollusk Venoms - genetics
Peptide Fragments - genetics
Phylogeny
Transcriptome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Predatory gastropods of the superfamily Conoidea number over 12,000 living species. The evolutionary success of this lineage can be explained by the ability of conoideans to produce complex venoms for hunting, defense, and competitive interactions. Whereas venoms of cone snails (family Conidae) have become increasingly well studied, the venoms of most other conoidean lineages remain largely uncharacterized. In the present study, we present the venom gland transcriptomes of two species of the genus Clavus that belong to the family Drilliidae. Venom gland transcriptomes of two specimens of Clavus canalicularis and two specimens of Clavus davidgilmouri were analyzed, leading to the identification of a total of 1,176 putative venom peptide toxins (drillipeptides). Based on the combined evidence of secretion signal sequence identity, entire precursor similarity search (BLAST), and the orthology inference, putative Clavus toxins were assigned to 158 different gene families. The majority of identified transcripts comprise signal, pro-, mature peptide, and post-regions, with a typically short (
ISSN:1759-6653
1759-6653
DOI:10.1093/gbe/evaa083