Development of child immunity in the context of COVID-19 pandemic

Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicat...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2020-08, Vol.217, p.108510-108510, Article 108510
Main Authors: Kloc, Małgorzata, Ghobrial, Rafik M., Kuchar, Ernest, Lewicki, Sławomir, Kubiak, Jacek Z.
Format: Article
Language:English
Subjects:
Adaptive immunology
Adult
Age Factors
Betacoronavirus - immunology
Betacoronavirus - pathogenicity
Child
Child immunity
Child, Preschool
Coronavirus Infections - epidemiology
Coronavirus Infections - immunology
Coronavirus Infections - transmission
Coronavirus Infections - virology
COVID-19
Cytokines - immunology
Disease Resistance
Female
Humans
Immune System - virology
Immune system development
Immunology
Incidence
Infant
Infant, Newborn
Innate immunity
Life Sciences
Macrophages
Milk, Human - immunology
Pandemics
Placenta - immunology
Placenta - virology
Pneumonia, Viral - epidemiology
Pneumonia, Viral - immunology
Pneumonia, Viral - transmission
Pneumonia, Viral - virology
Pregnancy
SARS-CoV-2
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Summary:Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children. •Children have immature immune system.•Maternally derived immunity protects against infection in the young children.•Rate and severity of COVID-19 are lower in children.•A different level of expression of ACE2 receptors in children than adults may protect from COVID-19.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2020.108510