Global resting‐state functional connectivity of neural oscillations in tinnitus with and without hearing loss

This study examined global resting‐state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus gro...

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Bibliographic Details
Published in:Human brain mapping 2020-07, Vol.41 (10), p.2846-2861
Main Authors: Demopoulos, Carly, Duong, Xuan, Hinkley, Leighton B., Ranasinghe, Kamalini G., Mizuiri, Danielle, Garrett, Coleman, Honma, Susanne, Henderson‐Sabes, Jennifer, Findlay, Anne, Racine‐Belkoura, Caroline, Cheung, Steven W., Nagarajan, Srikantan S.
Format: Article
Language:English
Subjects:
Biomarkers
electroencephalography
Frequencies
functional brain imaging
Hearing
Hearing loss
Hearing protection
magnetoencephalography
Oscillations
Tinnitus
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Summary:This study examined global resting‐state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band‐dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.24981