A Double-Edged Sword—Cardiovascular Concerns of Potential Anti-COVID-19 Drugs

Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 significantly affects multiple systems including the cardiovascular system. Most importantly, in addition to the direct injury from the virus per se, the subse...

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Bibliographic Details
Published in:Cardiovascular drugs and therapy 2021-04, Vol.35 (2), p.205-214
Main Authors: Yu, Wen-Liang, Toh, Han Siong, Liao, Chia-Te, Chang, Wei-Ting
Format: Article
Language:English
Subjects:
Antiviral agents
Antiviral Agents - pharmacology
Cardiology
Cardiotoxicity - prevention & control
Cardiovascular system
Cardiovascular System - drug effects
Coronaviruses
COVID-19
COVID-19 - drug therapy
COVID-19 - immunology
Cytokine storm
Cytokines
Disease control
Drug development
Drugs
Epidemics
Health risks
Humans
Immune system
Immunologic Factors - pharmacology
Immunomodulation
Immunosuppressive agents
Medicine
Medicine & Public Health
Pandemics
Review
Review Article
Risk Assessment
SARS-CoV-2 - drug effects
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viruses
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Summary:Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 significantly affects multiple systems including the cardiovascular system. Most importantly, in addition to the direct injury from the virus per se, the subsequent cytokine storm, an overproduction of immune cells and their activating compounds, causes devastating damage. To date, emerging anti-SARS-CoV-2 treatments are warranted to control epidemics. Several candidate drugs have been screened and are currently under investigation. These primarily include antiviral regimens and immunomodulatory regimens. However, beyond the anti-SARS-CoV-2 effects, these drugs may also have risks to the cardiovascular system, especially altering cardiac conduction. Herein, we review the cardiovascular risks of potential anti-COVID-19 drugs.
ISSN:0920-3206
1573-7241
DOI:10.1007/s10557-020-07024-7