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Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources
[Display omitted] Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare t...
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| Published in: | Acta biomaterialia 2018-07, Vol.74, p.56-73 |
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| container_title | Acta biomaterialia |
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| creator | Sun, Yu Yan, Lianqi Chen, Song Pei, Ming |
| description | [Display omitted]
Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare the differences between these dECMs when they serve as substrates for cartilage regeneration. In this review, after an introduction of cartilage immunogenicity and decellularization methods to prepare T-dECMs and C-dECMs, a comprehensive comparison focuses on the effects of T-dECMs and C-dECMs on proliferation and chondrogenic differentiation of chondrocytes/stem cells in vitro and in vivo. Key factors within dECMs, consisting of microarchitecture characteristics and micromechanical properties as well as retained insoluble and soluble matrix components, are discussed in-depth for potential mechanisms underlying the functionality of these dECMs in regulating chondrogenesis. With this information, we hope to benefit dECM based cartilage engineering and tissue regeneration for future clinical application.
The use of decellularized extracellular matrix (dECM) is becoming a promising approach for tissue engineering and regeneration. Compared to dECM derived from cartilage tissue, recently reported dECM from cell sources exhibits a distinct role in cell based cartilage regeneration. In this review paper, for the first time, tissue and cell based dECMs are comprehensively compared for their functionality in cartilage regeneration. This information is expected to provide an update for dECM based cartilage regeneration. |
| doi_str_mv | 10.1016/j.actbio.2018.04.048 |
| format | article |
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Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare the differences between these dECMs when they serve as substrates for cartilage regeneration. In this review, after an introduction of cartilage immunogenicity and decellularization methods to prepare T-dECMs and C-dECMs, a comprehensive comparison focuses on the effects of T-dECMs and C-dECMs on proliferation and chondrogenic differentiation of chondrocytes/stem cells in vitro and in vivo. Key factors within dECMs, consisting of microarchitecture characteristics and micromechanical properties as well as retained insoluble and soluble matrix components, are discussed in-depth for potential mechanisms underlying the functionality of these dECMs in regulating chondrogenesis. With this information, we hope to benefit dECM based cartilage engineering and tissue regeneration for future clinical application.
The use of decellularized extracellular matrix (dECM) is becoming a promising approach for tissue engineering and regeneration. Compared to dECM derived from cartilage tissue, recently reported dECM from cell sources exhibits a distinct role in cell based cartilage regeneration. In this review paper, for the first time, tissue and cell based dECMs are comprehensively compared for their functionality in cartilage regeneration. This information is expected to provide an update for dECM based cartilage regeneration.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2018.04.048</identifier><identifier>PMID: 29702288</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cartilage ; Cartilage - physiology ; Cartilage regeneration ; Cell growth ; Cell proliferation ; Chondrocyte ; Chondrocytes ; Chondrocytes - metabolism ; Chondrogenesis ; Chondrogenic differentiation ; Computer architecture ; Decellularized matrix ; Differentiation ; Extracellular matrix ; Extracellular Matrix - chemistry ; Humans ; Immunogenicity ; Proliferation ; Regeneration ; Reviews ; Stem cell ; Stem cells ; Stem Cells - metabolism ; Substrates ; Tissue engineering ; Tissue Engineering - methods</subject><ispartof>Acta biomaterialia, 2018-07, Vol.74, p.56-73</ispartof><rights>2018 Acta Materialia Inc.</rights><rights>Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Jul 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-19673a149153df6d37bef9c42a2a11ea5f8165fb88e770525709fcdf4f8540b03</citedby><cites>FETCH-LOGICAL-c594t-19673a149153df6d37bef9c42a2a11ea5f8165fb88e770525709fcdf4f8540b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29702288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Yan, Lianqi</creatorcontrib><creatorcontrib>Chen, Song</creatorcontrib><creatorcontrib>Pei, Ming</creatorcontrib><title>Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare the differences between these dECMs when they serve as substrates for cartilage regeneration. In this review, after an introduction of cartilage immunogenicity and decellularization methods to prepare T-dECMs and C-dECMs, a comprehensive comparison focuses on the effects of T-dECMs and C-dECMs on proliferation and chondrogenic differentiation of chondrocytes/stem cells in vitro and in vivo. Key factors within dECMs, consisting of microarchitecture characteristics and micromechanical properties as well as retained insoluble and soluble matrix components, are discussed in-depth for potential mechanisms underlying the functionality of these dECMs in regulating chondrogenesis. With this information, we hope to benefit dECM based cartilage engineering and tissue regeneration for future clinical application.
The use of decellularized extracellular matrix (dECM) is becoming a promising approach for tissue engineering and regeneration. Compared to dECM derived from cartilage tissue, recently reported dECM from cell sources exhibits a distinct role in cell based cartilage regeneration. In this review paper, for the first time, tissue and cell based dECMs are comprehensively compared for their functionality in cartilage regeneration. This information is expected to provide an update for dECM based cartilage regeneration.</description><subject>Animals</subject><subject>Cartilage</subject><subject>Cartilage - physiology</subject><subject>Cartilage regeneration</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Chondrocyte</subject><subject>Chondrocytes</subject><subject>Chondrocytes - metabolism</subject><subject>Chondrogenesis</subject><subject>Chondrogenic differentiation</subject><subject>Computer architecture</subject><subject>Decellularized matrix</subject><subject>Differentiation</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - chemistry</subject><subject>Humans</subject><subject>Immunogenicity</subject><subject>Proliferation</subject><subject>Regeneration</subject><subject>Reviews</subject><subject>Stem cell</subject><subject>Stem cells</subject><subject>Stem Cells - metabolism</subject><subject>Substrates</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kVFrFTEQhRex2Fr9ByIBX3zZ20k22WR9EEqxKhR80eeQzU6uuexurkn2Yv31Zrm1ah8KAwnkmzM5c6rqFYUNBdpe7DbG5t6HDQOqNsBLqSfVGVVS1VK06mm5S85qCS09rZ6ntANoFGXqWXXKOgmMKXVWjdfLbLMPsxl9viXBkQEtjuMymuh_4UAmk6P_SfxMrInZj2aLJOIWZ4xm7XtHLokN077gKcyrQPYpLUgOGNOSyCpGUliixfSiOnFmTPjy7jyvvl1_-Hr1qb758vHz1eVNbUXHc027VjaG8o6KZnDt0MgeXWc5M8xQikY4RVvheqVQShBMSOicHRx3SnDooTmv3h9190s_4WBxztGMeh_9ZOKtDsbr_19m_11vw0HLBiRQVgTe3gnE8GPBlPXk0-rEzBiWpBk0jANAJwv65gG6K2bLOldKdbRjqhGF4kfKxpBSRHf_GQp6jVPv9DFOvcapgZdSpe31v0bum_7k99cplnUePEadrMfZ4uAj2qyH4B-f8Bs5XLUy</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Sun, Yu</creator><creator>Yan, Lianqi</creator><creator>Chen, Song</creator><creator>Pei, Ming</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources</title><author>Sun, Yu ; Yan, Lianqi ; Chen, Song ; Pei, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-19673a149153df6d37bef9c42a2a11ea5f8165fb88e770525709fcdf4f8540b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cartilage</topic><topic>Cartilage - physiology</topic><topic>Cartilage regeneration</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Chondrocyte</topic><topic>Chondrocytes</topic><topic>Chondrocytes - metabolism</topic><topic>Chondrogenesis</topic><topic>Chondrogenic differentiation</topic><topic>Computer architecture</topic><topic>Decellularized matrix</topic><topic>Differentiation</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - chemistry</topic><topic>Humans</topic><topic>Immunogenicity</topic><topic>Proliferation</topic><topic>Regeneration</topic><topic>Reviews</topic><topic>Stem cell</topic><topic>Stem cells</topic><topic>Stem Cells - metabolism</topic><topic>Substrates</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Yan, Lianqi</creatorcontrib><creatorcontrib>Chen, Song</creatorcontrib><creatorcontrib>Pei, Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yu</au><au>Yan, Lianqi</au><au>Chen, Song</au><au>Pei, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>74</volume><spage>56</spage><epage>73</epage><pages>56-73</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare the differences between these dECMs when they serve as substrates for cartilage regeneration. In this review, after an introduction of cartilage immunogenicity and decellularization methods to prepare T-dECMs and C-dECMs, a comprehensive comparison focuses on the effects of T-dECMs and C-dECMs on proliferation and chondrogenic differentiation of chondrocytes/stem cells in vitro and in vivo. Key factors within dECMs, consisting of microarchitecture characteristics and micromechanical properties as well as retained insoluble and soluble matrix components, are discussed in-depth for potential mechanisms underlying the functionality of these dECMs in regulating chondrogenesis. With this information, we hope to benefit dECM based cartilage engineering and tissue regeneration for future clinical application.
The use of decellularized extracellular matrix (dECM) is becoming a promising approach for tissue engineering and regeneration. Compared to dECM derived from cartilage tissue, recently reported dECM from cell sources exhibits a distinct role in cell based cartilage regeneration. In this review paper, for the first time, tissue and cell based dECMs are comprehensively compared for their functionality in cartilage regeneration. This information is expected to provide an update for dECM based cartilage regeneration.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29702288</pmid><doi>10.1016/j.actbio.2018.04.048</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2018-07, Vol.74, p.56-73 |
| issn | 1742-7061 1878-7568 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Cartilage Cartilage - physiology Cartilage regeneration Cell growth Cell proliferation Chondrocyte Chondrocytes Chondrocytes - metabolism Chondrogenesis Chondrogenic differentiation Computer architecture Decellularized matrix Differentiation Extracellular matrix Extracellular Matrix - chemistry Humans Immunogenicity Proliferation Regeneration Reviews Stem cell Stem cells Stem Cells - metabolism Substrates Tissue engineering Tissue Engineering - methods |
| title | Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources |
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