Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration

ABSTRACT Ligament and tendon injuries are common problems in orthopedics. There is a need for treatments that can expedite nonoperative healing or improve the efficacy of surgical repair or reconstruction of ligaments and tendons. Successful biologically‐based attempts at repair and reconstruction w...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic research 2020-01, Vol.38 (1), p.7-12
Main Authors: Leong, Natalie L., Kator, Jamie L., Clemens, Thomas L., James, Aaron, Enamoto‐Iwamoto, Motomi, Jiang, Jie
Format: Article
Language:English
Subjects:
Animals
growth factors
Humans
ligament healing
Ligaments - anatomy & histology
Ligaments - injuries
Ligaments - physiology
pericytes
stem cells
tendon healing
Tendon Injuries - therapy
Tendons - anatomy & histology
Tendons - physiology
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Ligament and tendon injuries are common problems in orthopedics. There is a need for treatments that can expedite nonoperative healing or improve the efficacy of surgical repair or reconstruction of ligaments and tendons. Successful biologically‐based attempts at repair and reconstruction would require a thorough understanding of normal tendon and ligament healing. The inflammatory, proliferative, and remodeling phases, and the cells involved in tendon and ligament healing will be reviewed. Then, current research efforts focusing on biologically‐based treatments of ligament and tendon injuries will be summarized, with a focus on stem cells endogenous to tendons and ligaments. Statement of clinical significance: This paper details mechanisms of ligament and tendon healing, as well as attempts to apply stem cells to ligament and tendon healing. Understanding of these topics could lead to more efficacious therapies to treat ligament and tendon injuries. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:7–12, 2020
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.24475