Environmentally Persistent Free Radicals: Linking Air Pollution and Poor Respiratory Health?

Epidemiological relations between exposure to air pollution (both indoor and outdoor) and adverse respiratory outcomes, are examined. Although oxidative stress (OS) is presumed to be involved, a direct culprit is lacking. A proposal of a recently recognized by-product of thermal and combustion proce...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2019-10, Vol.200 (8), p.1062-1063
Main Authors: Sly, Peter D, Cormier, Stephania A, Lomnicki, Slawomir, Harding, Jeffrey N, Grimwood, Keith
Format: Article
Language:English
Subjects:
Air Pollutants - adverse effects
Air Pollutants - analysis
Air pollution
Air Pollution - adverse effects
Air Pollution - analysis
Biological activity
Correspondence
Environmental Exposure - adverse effects
Free radicals
Free Radicals - adverse effects
Humans
Oxidative stress
Particulate Matter - adverse effects
Particulate Matter - analysis
Respiratory diseases
Respiratory Tract Diseases - chemically induced
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Summary:Epidemiological relations between exposure to air pollution (both indoor and outdoor) and adverse respiratory outcomes, are examined. Although oxidative stress (OS) is presumed to be involved, a direct culprit is lacking. A proposal of a recently recognized by-product of thermal and combustion process that is capable of inducing OS as the missing link between exposure and respiratory disease, is presented. These products are called environmentally persistent free radicals (EPFRs). However, EPFRs persist in both the environment and biological systems for prolonged periods of time. An increasing number of studies are demonstrating the presence of EPFRs in a variety of environmental settings which include traffic-related air pollution (TRAP), coal dust and other combustion residues.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201903-0675LE