The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior: a Positron Emission Tomography Study

Purpose Radiotherapy is a frequently applied treatment modality for brain tumors. Concomitant irradiation of normal brain tissue can induce various physiological responses. The aim of this study was to investigate whether acute and early-delayed effects of brain irradiation on glial activation and b...

Full description

Saved in:
Bibliographic Details
Published in:Molecular imaging and biology 2020-08, Vol.22 (4), p.1012-1020
Main Authors: Parente, Andrea, de Vries, Erik F. J., van Waarde, Aren, Ioannou, Magdalini, van Luijk, Peter, Langendijk, Johannes A., Dierckx, Rudi A. J. O., Doorduin, Janine
Format: Article
Language:English
Subjects:
Activation
Brain
Brain cancer
Brain tumors
Cerebellum
Change detection
Cortex (frontal)
Cortex (motor)
Cortex (parietal)
Cortex (somatosensory)
Emission analysis
Field tests
Fluorine isotopes
Glucose
Glucose metabolism
Hypothalamus
Imaging
Inflammation
Irradiation
Medicine
Medicine & Public Health
Metabolism
Neostriatum
Neuroimaging
Neuronal-glial interactions
Nucleus accumbens
Open-field behavior
Physiological responses
Positron emission
Positron emission tomography
Radiation therapy
Radiology
Research Article
Sensorimotor integration
Septum
Tomography
Visual cortex
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Radiotherapy is a frequently applied treatment modality for brain tumors. Concomitant irradiation of normal brain tissue can induce various physiological responses. The aim of this study was to investigate whether acute and early-delayed effects of brain irradiation on glial activation and brain metabolism can be detected with positron emission tomography (PET) and whether these effects are correlated with behavioral changes. Procedures Rats underwent 0-, 10-, or 25-Gy whole-brain irradiation. At 3 and 31 days post irradiation, 1-(2-chlorophenyl)-N-[ 11 C]methyl-(1-methylpropyl)-3-isoquinoline carboxamide ([ 11 C]PK11195) and 2-deoxy-2-[ 18 F]fluoro- d -glucose ([ 18 F]FDG) PET scans were acquired to detect changes in glial activation (neuroinflammation) and glucose metabolism, respectively. The open-field test (OFT) was performed on days 6 and 27 to assess behavioral changes. Results Twenty-five-gray-irradiated rats showed higher [ 11 C]PK11195 uptake in most brain regions than controls on day 3 (striatum, hypothalamus, accumbens, septum p  
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-020-01483-y