Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study

Limited studies have examined the intestinal microbiota composition in relation to Crohn's disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing t...

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Published in:Journal of clinical medicine 2020-06, Vol.9 (6), p.1748
Main Authors: Park, Soo-Kyung, Kim, Han-Na, Choi, Chang Hwan, Im, Jong Pil, Cha, Jae Myung, Eun, Chang Soo, Kim, Tae-Oh, Kang, Sang-Bum, Bang, Ki Bae, Kim, Hyun Gun, Jung, Yunho, Yoon, Hyuk, Han, Dong-Soo, Lee, Chil-Woo, Ahn, Kwangsung, Kim, Hyung-Lae, Park, Dong Il
Format: Article
Language:English
Subjects:
Antibiotics
Biological products
Clinical medicine
Crohn's disease
Feces
Hospitalization
Hospitals
Inflammatory bowel disease
Microbiota
Pathogenesis
Probiotics
Steroids
Taxonomy
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Summary:Limited studies have examined the intestinal microbiota composition in relation to Crohn's disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota α-diversity decreased more in CD-P than CD-G and CD-I. Microbiota ß-diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups. ( = 0.001) and species ( = 0.01) and genera ( = 0.003) and Coprococcus ( = 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, and were the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, and might be causally involved in CD progression, and may have adapted to live in inflammatory environments.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9061748