The patterns of response of 11 regimens for infantile spasms

Infantile spasms (ISs) is a devastating form of an early infantile epileptic encephalopathy. The patterns of response of multiple regimens, and the difference in response rates for the cases who receive first-line therapies on time versus those who receive them after non-first-line therapies are unk...

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Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1), p.11509-11509, Article 11509
Main Authors: Mao, Leilei, Kessi, Miriam, Peng, Pan, He, Fang, Zhang, Ciliu, Yang, Lifen, Wu, Liwen, Yin, Fei, Peng, Jing
Format: Article
Language:English
Subjects:
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692/700
Adolescent
Anticonvulsants - administration & dosage
Child
Child, Preschool
China - epidemiology
Convulsions & seizures
Encephalopathy
Epilepsy
Female
Humanities and Social Sciences
Humans
Infant
Infants
Male
multidisciplinary
Response rates
Science
Science (multidisciplinary)
Seizures
Seizures - drug therapy
Seizures - epidemiology
Seizures - physiopathology
Spasms, Infantile - drug therapy
Spasms, Infantile - epidemiology
Spasms, Infantile - physiopathology
Statistical analysis
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Summary:Infantile spasms (ISs) is a devastating form of an early infantile epileptic encephalopathy. The patterns of response of multiple regimens, and the difference in response rates for the cases who receive first-line therapies on time versus those who receive them after non-first-line therapies are unknown. We performed a study involving 314 ISs cases aiming to investigate the patterns of response of 11 regimens, and the difference in response rates for the cases received first-line therapies as first two regimens versus those who received other drugs prior to first-line options. As a result, the efficacy of each regimen was: the foremost two regimens; 36.99%, third; 10.27%, fourth; 6.16%, fifth; 5.48%, and from the sixth regimen onwards, each additional regimen added ≤ 2% probability of seizure freedom. There was a statistically significant difference in seizure freedom rates between cases received first-line therapies as first or second regimen versus those who received them later. Our study revealed for the first time that in ISs cases, seizure freedom is likely to be observed within the first five regimens, and an early administration of first-line therapies is superior to non-first-line options. These results will aid in management of ISs cases.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-68403-6