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Mortality and the Use of Antithrombotic Therapies Among Nursing Home Residents with COVID‐19

BACKGROUND/OBJECTIVES Nursing home (NH) residents are a vulnerable population, susceptible to respiratory disease outbreaks such as coronavirus disease 2019 (COVID‐19). Poor outcome in COVID‐19 is at least partly attributed to hypercoagulability, resulting in a high incidence of thromboembolic compl...

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Published in:Journal of the American Geriatrics Society 2020-08, Vol.68 (8), p.1647-1652
Main Authors: Brouns, Steffie H., Brüggemann, Renée, Linkens, Aimée E. M. J. H., Magdelijns, Fabienne J., Joosten, Hanneke, Heijnen, Ron, Cate‐Hoek, Arina J., Schols, Jos M. G. A., Cate, Hugo, Spaetgens, Bart
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Language:English
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Summary:BACKGROUND/OBJECTIVES Nursing home (NH) residents are a vulnerable population, susceptible to respiratory disease outbreaks such as coronavirus disease 2019 (COVID‐19). Poor outcome in COVID‐19 is at least partly attributed to hypercoagulability, resulting in a high incidence of thromboembolic complications. It is unknown whether commonly used antithrombotic therapies may protect the vulnerable NH population with COVID‐19 against mortality. This study aimed to investigate whether the use of oral antithrombotic therapy (OAT) was associated with a lower mortality in NH residents with COVID‐19. DESIGN A retrospective case series. SETTING Fourteen NH facilities from the NH organization Envida, Maastricht, the Netherlands PARTICIPANTS A total of 101 NH residents with COVID‐19 were enrolled. MEASUREMENTS The primary outcome was all‐cause mortality. The association between age, sex, comorbidity, OAT, and mortality was assessed using logistic regression analysis. RESULTS Overall mortality was 47.5% in NH residents from 14 NH facilities. Age, comorbidity, and medication use were comparable among NH residents who survived and who died. OAT was associated with a lower mortality in NH residents with COVID‐19 in the univariable analysis (odds ratio (OR) = 0.89; 95% confidence interval (CI) = 0.41–1.95). However, additional adjustments for sex, age, and comorbidity attenuated this difference. Mortality in males was higher compared with female residents (OR = 3.96; 95% CI = 1.62–9.65). Male residents who died were younger compared with female residents (82.2 (standard deviation (SD) = 6.3) vs 89.1 (SD = 6.8) years; P 
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.16664