Physics of Nanomechanical Spectrometry of Viruses

There is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a...

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Bibliographic Details
Published in:Scientific reports 2014-08, Vol.4 (1), p.6051, Article 6051
Main Authors: Ruz, J. J., Tamayo, J., Pini, V., Kosaka, P. M., Calleja, M.
Format: Article
Language:English
Subjects:
101/58
631/57/2282
639/925/927/359
9/10
Adsorption
Algorithms
Anisotropy
Elastic Modulus - physiology
Humanities and Social Sciences
Magnetic Resonance Spectroscopy - methods
Mechanical Phenomena
Mechanical properties
Models, Theoretical
multidisciplinary
Nanotechnology
Nanotechnology - methods
Nanotubes
Science
Scientific imaging
Silicon
Silicon Compounds
Silicon nitride
Spectrometry
Theoretical analysis
Tobacco Mosaic Virus - physiology
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Summary:There is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a detailed theoretical analysis to calculate the resonance frequency shift induced by the mechanical stiffness of viral nanotubes. The model accounts for the high surface-to-volume ratio featured by single biological entities, the shape anisotropy and the interfacial adhesion. The model is applied to the case in which tobacco mosaic virus is randomly delivered to a silicon nitride cantilever. The theoretical framework opens the door to a novel paradigm for biological spectrometry as well as for measuring the Young's modulus of biological systems with minimal strains.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep06051