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Gender‐specific association between body mass index and all‐cause mortality in patients with atrial fibrillation
Background Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases. Hypothesis Gender‐specific association between BMI and mortality exists in atrial fibrillation (AF). Methods In this multicenter observational study with a mean follow‐up of 1 year, a tota...
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| Published in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2020-07, Vol.43 (7), p.706-714 |
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| cites | cdi_FETCH-LOGICAL-c4431-61837927c906b6398a7e2f018c51839ab0fe1372e87b367597eb58e8b2809b333 |
| container_end_page | 714 |
| container_issue | 7 |
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| container_title | Clinical cardiology (Mahwah, N.J.) |
| container_volume | 43 |
| creator | Lyu, Si‐qi Yang, Yan‐min Zhu, Jun Wang, Juan Wu, Shuang Zhang, Han Shao, Xing‐hui Ren, Jia‐meng |
| description | Background
Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases.
Hypothesis
Gender‐specific association between BMI and mortality exists in atrial fibrillation (AF).
Methods
In this multicenter observational study with a mean follow‐up of 1 year, a total of 1991 AF patients were enrolled and divided into two groups based on the gender. The primary endpoint was all‐cause mortality while the secondary endpoints were defined as cardiovascular mortality, stroke, and major adverse events during 1‐year follow‐up. Cox regression was performed to identify the association between BMI and clinical outcomes according to gender.
Results
Female patients with AF tended to be older (P = .027) and thinner (P |
| doi_str_mv | 10.1002/clc.23371 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7368315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2396853898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4431-61837927c906b6398a7e2f018c51839ab0fe1372e87b367597eb58e8b2809b333</originalsourceid><addsrcrecordid>eNp1kcGKFDEQhoMo7rh68AUk4EUPvZukujvJRZBBV2HAi55DOlPtZkl3xiS949x8BJ_RJzHurIsKnurwf_VRxU_IU87OOGPi3AV3JgAkv0dWXINolAR5n6wY71mjhdIn5FHOVxVlSsBDcgICOtGpdkXKBc5bTD--fc87dH70jtqco_O2-DjTAcsesc64PdCpJtRX_Cu185baEOqas0tGOsVUbPDlUHO6q7s4l0z3vlxSW5K3gY5-SD6EG-1j8mC0IeOT23lKPr1983H9rtl8uHi_fr1pXNsCb3quQGohnWb90INWVqIYGVeuq4m2AxuRgxSo5AC97LTEoVOoBqGYHgDglLw6enfLMOHW1aOSDWaX_GTTwUTrzd_J7C_N53htJPQKeFcFL24FKX5ZMBcz-eywvjFjXLIRoHvVgdKqos__Qa_ikub6nhGtaHuhoWsr9fJIuRRzTjjeHcOZ-dWlqV2amy4r--zP6-_I3-VV4PwI7H3Aw_9NZr1ZH5U_ASD-q6Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424629354</pqid></control><display><type>article</type><title>Gender‐specific association between body mass index and all‐cause mortality in patients with atrial fibrillation</title><source>PubMed (Medline)</source><source>Access via ProQuest (Open Access)</source><source>Wiley Online Library Open Access</source><creator>Lyu, Si‐qi ; Yang, Yan‐min ; Zhu, Jun ; Wang, Juan ; Wu, Shuang ; Zhang, Han ; Shao, Xing‐hui ; Ren, Jia‐meng</creator><creatorcontrib>Lyu, Si‐qi ; Yang, Yan‐min ; Zhu, Jun ; Wang, Juan ; Wu, Shuang ; Zhang, Han ; Shao, Xing‐hui ; Ren, Jia‐meng</creatorcontrib><description>Background
Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases.
Hypothesis
Gender‐specific association between BMI and mortality exists in atrial fibrillation (AF).
Methods
In this multicenter observational study with a mean follow‐up of 1 year, a total of 1991 AF patients were enrolled and divided into two groups based on the gender. The primary endpoint was all‐cause mortality while the secondary endpoints were defined as cardiovascular mortality, stroke, and major adverse events during 1‐year follow‐up. Cox regression was performed to identify the association between BMI and clinical outcomes according to gender.
Results
Female patients with AF tended to be older (P = .027) and thinner (P < .001) than male patients with AF. They were more likely to have heart failure, hyperthyroidism, and valvular AF (all P < .05), but less likely to have coronary artery disease and prior myocardial infarction (all P < .01). Multivariate analysis revealed that overweight (HR(95%CI): 0.55(0.41‐0.75), P < .001) and obese patients (HR(95%CI): 0.56(0.34‐0.94), P = .028) were associated with significant lower all‐cause mortality compared with normal weight patients for the entire cohort. Similar association between elevated BMI and reduced all‐cause mortality were only identified in female patients with AF (overweight vs normal weight: HR(95%CI): 0.43(0.27‐0.70); obesity vs normal weight: HR(95%CI): 0.46(0.22‐0.97)), but not in male patients with AF.
Conclusion
This study indicates that overweight and obesity were related with improved survival in patients with AF. The association between elevated BMI and reduced mortality was dependent on gender, which was only significant in female patients, rather than male patients.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.23371</identifier><identifier>PMID: 32352584</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>all‐cause mortality ; Anticoagulants ; atrial fibrillation ; Body mass index ; Cardiovascular disease ; Clinical Investigations ; Congenital diseases ; gender ; Health risk assessment ; Mortality ; Obesity</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2020-07, Vol.43 (7), p.706-714</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2020 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-61837927c906b6398a7e2f018c51839ab0fe1372e87b367597eb58e8b2809b333</citedby><cites>FETCH-LOGICAL-c4431-61837927c906b6398a7e2f018c51839ab0fe1372e87b367597eb58e8b2809b333</cites><orcidid>0000-0001-9594-8133</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2424629354/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2424629354?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,37013,44590,46052,46476,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32352584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyu, Si‐qi</creatorcontrib><creatorcontrib>Yang, Yan‐min</creatorcontrib><creatorcontrib>Zhu, Jun</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Wu, Shuang</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Shao, Xing‐hui</creatorcontrib><creatorcontrib>Ren, Jia‐meng</creatorcontrib><title>Gender‐specific association between body mass index and all‐cause mortality in patients with atrial fibrillation</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Background
Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases.
Hypothesis
Gender‐specific association between BMI and mortality exists in atrial fibrillation (AF).
Methods
In this multicenter observational study with a mean follow‐up of 1 year, a total of 1991 AF patients were enrolled and divided into two groups based on the gender. The primary endpoint was all‐cause mortality while the secondary endpoints were defined as cardiovascular mortality, stroke, and major adverse events during 1‐year follow‐up. Cox regression was performed to identify the association between BMI and clinical outcomes according to gender.
Results
Female patients with AF tended to be older (P = .027) and thinner (P < .001) than male patients with AF. They were more likely to have heart failure, hyperthyroidism, and valvular AF (all P < .05), but less likely to have coronary artery disease and prior myocardial infarction (all P < .01). Multivariate analysis revealed that overweight (HR(95%CI): 0.55(0.41‐0.75), P < .001) and obese patients (HR(95%CI): 0.56(0.34‐0.94), P = .028) were associated with significant lower all‐cause mortality compared with normal weight patients for the entire cohort. Similar association between elevated BMI and reduced all‐cause mortality were only identified in female patients with AF (overweight vs normal weight: HR(95%CI): 0.43(0.27‐0.70); obesity vs normal weight: HR(95%CI): 0.46(0.22‐0.97)), but not in male patients with AF.
Conclusion
This study indicates that overweight and obesity were related with improved survival in patients with AF. The association between elevated BMI and reduced mortality was dependent on gender, which was only significant in female patients, rather than male patients.</description><subject>all‐cause mortality</subject><subject>Anticoagulants</subject><subject>atrial fibrillation</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Clinical Investigations</subject><subject>Congenital diseases</subject><subject>gender</subject><subject>Health risk assessment</subject><subject>Mortality</subject><subject>Obesity</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><recordid>eNp1kcGKFDEQhoMo7rh68AUk4EUPvZukujvJRZBBV2HAi55DOlPtZkl3xiS949x8BJ_RJzHurIsKnurwf_VRxU_IU87OOGPi3AV3JgAkv0dWXINolAR5n6wY71mjhdIn5FHOVxVlSsBDcgICOtGpdkXKBc5bTD--fc87dH70jtqco_O2-DjTAcsesc64PdCpJtRX_Cu185baEOqas0tGOsVUbPDlUHO6q7s4l0z3vlxSW5K3gY5-SD6EG-1j8mC0IeOT23lKPr1983H9rtl8uHi_fr1pXNsCb3quQGohnWb90INWVqIYGVeuq4m2AxuRgxSo5AC97LTEoVOoBqGYHgDglLw6enfLMOHW1aOSDWaX_GTTwUTrzd_J7C_N53htJPQKeFcFL24FKX5ZMBcz-eywvjFjXLIRoHvVgdKqos__Qa_ikub6nhGtaHuhoWsr9fJIuRRzTjjeHcOZ-dWlqV2amy4r--zP6-_I3-VV4PwI7H3Aw_9NZr1ZH5U_ASD-q6Y</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Lyu, Si‐qi</creator><creator>Yang, Yan‐min</creator><creator>Zhu, Jun</creator><creator>Wang, Juan</creator><creator>Wu, Shuang</creator><creator>Zhang, Han</creator><creator>Shao, Xing‐hui</creator><creator>Ren, Jia‐meng</creator><general>Wiley Periodicals, Inc</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9594-8133</orcidid></search><sort><creationdate>202007</creationdate><title>Gender‐specific association between body mass index and all‐cause mortality in patients with atrial fibrillation</title><author>Lyu, Si‐qi ; Yang, Yan‐min ; Zhu, Jun ; Wang, Juan ; Wu, Shuang ; Zhang, Han ; Shao, Xing‐hui ; Ren, Jia‐meng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-61837927c906b6398a7e2f018c51839ab0fe1372e87b367597eb58e8b2809b333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>all‐cause mortality</topic><topic>Anticoagulants</topic><topic>atrial fibrillation</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Clinical Investigations</topic><topic>Congenital diseases</topic><topic>gender</topic><topic>Health risk assessment</topic><topic>Mortality</topic><topic>Obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyu, Si‐qi</creatorcontrib><creatorcontrib>Yang, Yan‐min</creatorcontrib><creatorcontrib>Zhu, Jun</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Wu, Shuang</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Shao, Xing‐hui</creatorcontrib><creatorcontrib>Ren, Jia‐meng</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley-Blackwell Open Access Backfiles (Open Access)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyu, Si‐qi</au><au>Yang, Yan‐min</au><au>Zhu, Jun</au><au>Wang, Juan</au><au>Wu, Shuang</au><au>Zhang, Han</au><au>Shao, Xing‐hui</au><au>Ren, Jia‐meng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender‐specific association between body mass index and all‐cause mortality in patients with atrial fibrillation</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2020-07</date><risdate>2020</risdate><volume>43</volume><issue>7</issue><spage>706</spage><epage>714</epage><pages>706-714</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><abstract>Background
Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases.
Hypothesis
Gender‐specific association between BMI and mortality exists in atrial fibrillation (AF).
Methods
In this multicenter observational study with a mean follow‐up of 1 year, a total of 1991 AF patients were enrolled and divided into two groups based on the gender. The primary endpoint was all‐cause mortality while the secondary endpoints were defined as cardiovascular mortality, stroke, and major adverse events during 1‐year follow‐up. Cox regression was performed to identify the association between BMI and clinical outcomes according to gender.
Results
Female patients with AF tended to be older (P = .027) and thinner (P < .001) than male patients with AF. They were more likely to have heart failure, hyperthyroidism, and valvular AF (all P < .05), but less likely to have coronary artery disease and prior myocardial infarction (all P < .01). Multivariate analysis revealed that overweight (HR(95%CI): 0.55(0.41‐0.75), P < .001) and obese patients (HR(95%CI): 0.56(0.34‐0.94), P = .028) were associated with significant lower all‐cause mortality compared with normal weight patients for the entire cohort. Similar association between elevated BMI and reduced all‐cause mortality were only identified in female patients with AF (overweight vs normal weight: HR(95%CI): 0.43(0.27‐0.70); obesity vs normal weight: HR(95%CI): 0.46(0.22‐0.97)), but not in male patients with AF.
Conclusion
This study indicates that overweight and obesity were related with improved survival in patients with AF. The association between elevated BMI and reduced mortality was dependent on gender, which was only significant in female patients, rather than male patients.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>32352584</pmid><doi>10.1002/clc.23371</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9594-8133</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cardiology (Mahwah, N.J.), 2020-07, Vol.43 (7), p.706-714 |
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| language | eng |
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| source | PubMed (Medline); Access via ProQuest (Open Access); Wiley Online Library Open Access |
| subjects | all‐cause mortality Anticoagulants atrial fibrillation Body mass index Cardiovascular disease Clinical Investigations Congenital diseases gender Health risk assessment Mortality Obesity |
| title | Gender‐specific association between body mass index and all‐cause mortality in patients with atrial fibrillation |
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