Transient phlebitis: an unusual effect of intravenous diphenhydramine

Causative agents may be mechanical (size, location, composition of intravenous cannula), chemical (drugs, infusates) or biological (infections). Old age, thin body habitus and atopic tendency have also been thought to increase incidence and severity.5 Transient phlebitis has been described after int...

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Bibliographic Details
Published in:BMJ case reports 2020-07, Vol.13 (7), p.e237273
Main Authors: Manchegowda, Shashidhar N, Zbeidy, Reine, Souki, Fouad G
Format: Article
Language:English
Subjects:
Adult
anaesthesia
Antibiotics
Case reports
Catheterization
contraindications and precautions
Diphenhydramine - administration & dosage
Diphenhydramine - adverse effects
drugs and medicines
Erythema
Erythema - chemically induced
Erythema - therapy
Forearm - blood supply
Hand - blood supply
Humans
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - adverse effects
Images In
Kidney Failure, Chronic - surgery
Male
Morphine
Pain
Phlebitis
Phlebitis - chemically induced
safety
unwanted effects / adverse reactions
Veins
Veins & arteries
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Summary:Causative agents may be mechanical (size, location, composition of intravenous cannula), chemical (drugs, infusates) or biological (infections). Old age, thin body habitus and atopic tendency have also been thought to increase incidence and severity.5 Transient phlebitis has been described after intravenous administration of several drugs (meperidine, morphine, rocuronium, propofol, eptifibatide and ciprofloxacin).5–10 Hypothesised mechanisms associated with this phenomenon include tissue damage, local mediator release, histamine release, direct activation of C-nociceptors and activation of kallikrein-kinin system with bradykinin generation.5 6 Diphenhydramine is an antihistamine (H-1 receptor antagonist) with anticholinergic and sedative effects. Infusion phlebitis assessment measures: a systematic review.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2020-237273