Depletion of langerin+ cells enhances cutaneous wound healing

Summary Langerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thicknes...

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Bibliographic Details
Published in:Immunology 2020-08, Vol.160 (4), p.366-381
Main Authors: Rajesh, Aarthi, Stuart, Gabriella, Real, Nicola, Ahn, Jenny, Tschirley, Allison, Wise, Lyn, Hibma, Merilyn
Format: Article
Language:English
Subjects:
Ablation
angiogenesis
Blood vessels
Dendritic cells
Depletion
Epidermis
epithelialization
Granulation
Langerhans cells
langerin‐positive dermal dendritic cells
Leukocytes (granulocytic)
Macrophages
mouse
Original
skin
Tissues
Wound healing
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Summary:Summary Langerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thickness excision wound were investigated using the langerin‐DTR depletable mouse. Strikingly, depletion of langerin+ cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin+‐cell‐depleted group was characterized by enhanced neo‐epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin+ cells was associated with increased levels of granulocyte–macrophage colony‐stimulating factor, F4/80+ cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin+ cells during wound healing. Therapies that suppress langerin+ cells or their function may therefore have utility in progressing the healing of wounds in humans. Ablation of langerin‐positive cells in the langerin‐DTR depletable mouse accelerates healing of a full‐thickness cutaneous wound. Neo‐epidermis and granulation tissue formation was increased, associated with increased cellular proliferation, F4/80‐positive cell infiltration, GM‐CSF production and granulation tissue vascularization. These data provide evidence of a diverse role for langerin‐positive cells in the regulation of wound healing.
ISSN:0019-2805
1365-2567
DOI:10.1111/imm.13202