Functional lupus anticoagulant testing in a large retrospective cohort of thrombosis patients with direct oral anticoagulants

Functional tests for lupus anticoagulants (LA) as part of a thrombophilia workup are commonly performed in patients under anticoagulant therapy that may interfere with assay results. There is no consensus on how these tests should be assessed in patients on direct oral anticoagulants (DOACs). In thi...

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Published in:Scientific reports 2020-07, Vol.10 (1), p.12221-12221, Article 12221
Main Authors: Reda, Sara, Brügelmann, Anna, Müller, Jens, Oldenburg, Johannes, Pötzsch, Bernd, Rühl, Heiko
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Language:English
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692/53/2421
692/699/75/593/1839
Anticoagulants
Antiphospholipid antibodies
Humanities and Social Sciences
Lupus
multidisciplinary
Plasma levels
Science
Science (multidisciplinary)
Systemic lupus erythematosus
Thromboembolism
Thrombophilia
Thrombosis
Venom
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description Functional tests for lupus anticoagulants (LA) as part of a thrombophilia workup are commonly performed in patients under anticoagulant therapy that may interfere with assay results. There is no consensus on how these tests should be assessed in patients on direct oral anticoagulants (DOACs). In this retrospective cohort study, we analysed data from patients with a history of thrombosis in whom dilute Russell viper venom time (dRVVT), LA-sensitive aPTT, and solid phase assays for antiphospholipid antibodies (aPL) were performed (n = 3,147, thereof 588 on rivaroxaban, 144 on apixaban, 1,179 on other anticoagulant drugs). The dRVVT ratio was correlated with rivaroxaban (r = 0.30, P  
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subjects 692/53/2421
692/699/75/593/1839
Anticoagulants
Antiphospholipid antibodies
Humanities and Social Sciences
Lupus
multidisciplinary
Plasma levels
Science
Science (multidisciplinary)
Systemic lupus erythematosus
Thromboembolism
Thrombophilia
Thrombosis
Venom
title Functional lupus anticoagulant testing in a large retrospective cohort of thrombosis patients with direct oral anticoagulants
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