Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance

Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In th...

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Published in:Translational psychiatry 2020-07, Vol.10 (1), p.252-252, Article 252
Main Authors: Sun, Jie, Yan, Wei, Zhang, Xing-Nan, Lin, Xiao, Li, Hui, Gong, Yi-Miao, Zhu, Xi-Mei, Zheng, Yong-Bo, Guo, Xiang-Yang, Ma, Yun-Dong, Liu, Zeng-Yi, Liu, Lin, Gao, Jia-Hong, Vitiello, Michael V., Chang, Su-Hua, Liu, Xiao-Guang, Lu, Lin
Format: Article
Language:English
Subjects:
631/208/212
631/378
Behavioral Sciences
Biological Psychology
Chronic pain
Comorbidity
Medicine
Medicine & Public Health
Neurosciences
Pain
Pharmacotherapy
Psychiatry
Sleep
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Summary:Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In this study, we combined 1206 participants with phenotype data, resting-state functional magnetic resonance imaging (rfMRI) data and genotype data from the Human Connectome Project and two large sample size genome-wide association studies (GWASs) summary data from published studies to identify the genetic and neural bases for the association between pain and sleep disturbance. Pittsburgh sleep quality index (PSQI) score was used for sleep disturbance, pain intensity was measured by Pain Intensity Survey. The result showed chronic pain was significantly correlated with sleep disturbance ( r  = 0.171, p -value 
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-020-00941-z