Modulation of inhibitory control networks relate to clinical response following ketamine therapy in major depression

Subanesthetic ketamine is found to induce fast-acting and pronounced antidepressant effects, even in treatment resistant depression (TRD). However, it remains unclear how ketamine modulates neural function at the brain systems-level to regulate emotion and behavior. Here, we examined treatment-relat...

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Bibliographic Details
Published in:Translational psychiatry 2020-07, Vol.10 (1), p.260-260, Article 260
Main Authors: Sahib, Ashish K., Loureiro, Joana RA, Vasavada, Megha M., Kubicki, Antoni, Wade, Benjamin, Joshi, Shantanu H., Woods, Roger P., Congdon, Eliza, Espinoza, Randall, Narr, Katherine L.
Format: Article
Language:English
Subjects:
631/154/53/2423
692/53/2421
Adult
Antidepressive Agents - therapeutic use
Behavioral Sciences
Biological Psychology
Depression
Depressive Disorder, Major - drug therapy
Depressive Disorder, Treatment-Resistant - diagnostic imaging
Depressive Disorder, Treatment-Resistant - drug therapy
Female
Humans
Ketamine
Ketamine - therapeutic use
Medicine
Medicine & Public Health
Neurosciences
Pharmacotherapy
Psychiatry
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Summary:Subanesthetic ketamine is found to induce fast-acting and pronounced antidepressant effects, even in treatment resistant depression (TRD). However, it remains unclear how ketamine modulates neural function at the brain systems-level to regulate emotion and behavior. Here, we examined treatment-related changes in the inhibitory control network after single and repeated ketamine therapy in TRD. Forty-seven TRD patients (mean age = 38, 19 women) and 32 healthy controls (mean age = 35, 18 women) performed a functional magnetic resonance imaging (fMRI) response inhibition task at baseline, and 37 patients completed the fMRI task and symptom scales again 24 h after receiving both one and four 0.5 mg/kg intravenous ketamine infusions. Analyses of fMRI data addressed effects of diagnosis, time, and differences between treatment remitters and non-remitters. Significant decreases in brain activation were observed in the inhibitory control network, including in prefrontal and parietal regions, and visual cortex following serial ketamine treatment, p  
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-020-00947-7