Liver Chemistries in Patients With COVID‐19 Who Were Discharged Alive or Died: A Meta‐analysis

Although abnormal liver chemistries are linked to a higher risk of coronavirus disease 2019 (COVID‐19)–related death, liver manifestations may be diverse and even confusing. Thus, we performed a meta‐analysis of published liver manifestations and described the liver damage in patients with COVID‐19...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology Communications 2021-01, Vol.5 (1), p.12-23
Main Authors: Xing, Qing‐Qing, Dong, Xuan, Ren, Yan‐Dan, Chen, Wei‐Ming, Zeng, Dan‐Yi, Cai, Yan‐Yan, Hong, Mei‐Zhu, Pan, Jin‐Shui
Format: Article
Language:English
Subjects:
COVID-19
Fatalities
Meta-analysis
Middle East respiratory syndrome
Mortality
Original
Pandemics
Respiratory diseases
Citations: Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although abnormal liver chemistries are linked to a higher risk of coronavirus disease 2019 (COVID‐19)–related death, liver manifestations may be diverse and even confusing. Thus, we performed a meta‐analysis of published liver manifestations and described the liver damage in patients with COVID‐19 who died or discharged alive. We searched PubMed, Google Scholar, medRxiv, bioRxiv, the Cochrane Library, Embase, and three Chinese electronic databases through April 22, 2020. We analyzed pooled data on liver chemistries stratified by the main clinical outcome of COVID‐19, using a fixed or random‐effects model. In our meta‐analysis of 19 studies, which included a total of 4,103 patients, the pooled mean alanine aminotransferase and aspartate aminotransferase levels were, respectively, 31.7 IU/L and 51.0 IU/L in the patients with COVID‐19 who died and 27.7 IU/L and 32.9 IU/L in those discharged alive (both P 
ISSN:2471-254X
2471-254X
DOI:10.1002/hep4.1585