Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics

The Fontan procedure is a common palliative surgery for congenital single ventricle patients. In silico and in vitro patient-specific modeling approaches are widely utilized to investigate potential improvements of Fontan hemodynamics that are related to long-term complications. However, there is a...

Full description

Saved in:
Bibliographic Details
Published in:Annals of biomedical engineering 2020-08, Vol.48 (8), p.2204-2217
Main Authors: Wei, Zhenglun, Singh-Gryzbon, Shelly, Trusty, Phillip M., Huddleston, Connor, Zhang, Yingnan, Fogel, Mark A., Veneziani, Alessandro, Yoganathan, Ajit P.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Classical Mechanics
Computer simulation
Flow distribution
Heart surgery
Hemodynamics
Mathematical analysis
Modelling
Original Article
Rheological properties
Rheology
Shear stress
Ventricle
Wall shear stresses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Fontan procedure is a common palliative surgery for congenital single ventricle patients. In silico and in vitro patient-specific modeling approaches are widely utilized to investigate potential improvements of Fontan hemodynamics that are related to long-term complications. However, there is a lack of consensus regarding the use of non-Newtonian rheology, warranting a systematic investigation. This study conducted in silico patient-specific modeling for twelve Fontan patients, using a Newtonian and a non-Newtonian model for each patient. Differences were quantified by examining clinically relevant metrics: indexed power loss (iPL), indexed viscous dissipation rate (iVDR), hepatic flow distribution (HFD), and regions of low wall shear stress ( A WSS ). Four sets of “non-Newtonian importance factors” were calculated to explore their effectiveness in identifying the non-Newtonian effect. No statistical differences were observed in iPL, iVDR, and HFD between the two models at the population-level, but large inter-patient variations exist. Significant differences were detected regarding A WSS , and its correlations with non-Newtonian importance factors were discussed. Additionally, simulations using the non-Newtonian model were computationally faster than those using the Newtonian model. These findings distinguish good importance factors for identifying non-Newtonian rheology and encourage the use of a non-Newtonian model to assess Fontan hemodynamics.
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-020-02527-8