Polygenic risk score analysis revealed shared genetic background in attention deficit hyperactivity disorder and narcolepsy

Attention deficit hyperactive disorder (ADHD) is a highly heritable neurodevelopmental disorder, and excessive daytime sleepiness is frequently observed in ADHD patients. Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable condi...

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Bibliographic Details
Published in:Translational psychiatry 2020-08, Vol.10 (1), p.284-284, Article 284
Main Authors: Takahashi, Nagahide, Nishimura, Tomoko, Harada, Taeko, Okumura, Akemi, Choi, Damee, Iwabuchi, Toshiki, Kuwabara, Hitoshi, Takagai, Shu, Nomura, Yoko, Newcorn, Jeffrey. H., Takei, Nori, Tsuchiya, Kenji J.
Format: Article
Language:English
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45/43
631/208/2489
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Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Behavioral Sciences
Biological Psychology
Child
Genetic Background
Genome-Wide Association Study
Humans
Hyperactivity
Medicine
Medicine & Public Health
Narcolepsy - genetics
Neurodevelopmental disorders
Neurosciences
Pharmacotherapy
Psychiatry
Risk Factors
Sleep disorders
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Summary:Attention deficit hyperactive disorder (ADHD) is a highly heritable neurodevelopmental disorder, and excessive daytime sleepiness is frequently observed in ADHD patients. Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable conditions. Psychostimulants are effective for the symptomatic control of ADHD (primary recommended intervention) and the two sleep disorders (frequent off-label use). However, the common biological mechanism for these disorders has not been well understood. Using a previously collected genome-wide association study of narcolepsy and EHS, we calculated polygenic risk scores (PRS) for each individual. We investigated a possible genetic association between ADHD and narcolepsy traits in the Hamamatsu Birth Cohort for mothers and children (HBC study) ( n  = 876). Gene-set enrichment analyses were used to identify common pathways underlying these disorders. Narcolepsy PRS were significantly associated with ADHD traits both in the hyperactivity domain (e.g., P -value threshold
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-020-00971-7