Seroprevalence of H7N9 infection among humans: A systematic review and meta‐analysis

In spring 2013, a novel avian‐origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta‐analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled...

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Bibliographic Details
Published in:Influenza and other respiratory viruses 2020-09, Vol.14 (5), p.587-595
Main Authors: Wang, Qiang, Xu, Ke, Xie, Weihua, Yang, Liuqing, Chen, Haiyan, Shi, Naiyang, Bao, Changjun, Huang, Haodi, Zhang, Xuefeng, Liao, Yilan, Jin, Hui
Format: Article
Language:English
Subjects:
Antigens
Asymptomatic infection
Confidence intervals
Fatalities
Formal Systematic Review (Commissioned or Non‐commissioned)
H7N9
Infections
Influenza
Influenza A
Meta-analysis
Population
Researchers
Respiratory diseases
Sample size
Serology
seroprevalence
Software
Studies
systematic review
Viruses
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Summary:In spring 2013, a novel avian‐origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta‐analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman‐Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta‐analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high‐risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.
ISSN:1750-2640
1750-2659
DOI:10.1111/irv.12736