Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐Analysis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-01, Vol.73 (1), p.36-47
• Main Authors: Putman, Michael, Chock, Yu Pei Eugenia, Tam, Herman, Kim, Alfred H. J., Sattui, Sebastian E., Berenbaum, Francis, Danila, Maria I., Korsten, Peter, Sanchez-Alvarez, Catalina, Sparks, Jeffrey A., Coates, Laura C., Palmerlee, Candace, Peirce, Andrea, Jayatilleke, Arundathi, Johnson, Sindhu R., Kilian, Adam, Liew, Jean, Prokop, Larry J., Murad, M. Hassan, Grainger, Rebecca, Wallace, Zachary S., Duarte-García, Alí
• Format: Article
• Language: English
• Subjects: Antibodies, Monoclonal - therapeutic use; Antibodies, Monoclonal, Humanized - therapeutic use; Antirheumatic Agents - therapeutic use; Azetidines - therapeutic use; Bias; Chloroquine - therapeutic use; Clinical trials; Complications; Confidence intervals; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - mortality; COVID-19 - physiopathology; COVID-19 Drug Treatment; Disease Progression; Full Length; Glucocorticoids - therapeutic use; Humans; Hydroxychloroquine; Hydroxychloroquine - therapeutic use; Immunoglobulins, Intravenous - therapeutic use; Immunologic Factors - therapeutic use; Interleukin 1 receptor antagonist; Interleukin 1 Receptor Antagonist Protein - therapeutic use; Janus Kinase Inhibitors - therapeutic use; Medical treatment; Meta-analysis; Mortality; Patients; Proportional Hazards Models; Purines - therapeutic use; Pyrazoles - therapeutic use; Respiratory diseases; Risk assessment; SARS-CoV-2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Sulfonamides - therapeutic use; Systematic review; Viral diseases
• ISSN: 2326-5191; 2326-5205
• DOI: 10.1002/art.41469

Objective Antirheumatic disease therapies have been used to treat coronavirus disease 2019 (COVID‐19) and its complications. We conducted a systematic review and meta‐analysis to describe the current evidence. Methods A search of published and preprint databases in all languages was performed. Included studies described ≥1 relevant clinical outcome for ≥5 patients who were infected with severe acute respiratory syndrome coronavirus 2 and were treated with antirheumatic disease therapy between January 1, 2019 and May 29, 2020. Pairs of reviewers screened articles, extracted data, and assessed risk of bias. A meta‐analysis of effect sizes using random‐effects models was performed when possible. Results The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients, and 29 of the 45 studies had been published in a peer‐reviewed journal. In a meta‐analysis of 3 cohort studies with a low risk of bias, hydroxychloroquine use was not significantly associated with mortality (pooled hazard ratio [HR] 1.41 [95% confidence interval (95% CI) 0.83, 2.42]). In a meta‐analysis of 2 cohort studies with some concerns/higher risk of bias, anakinra use was associated with lower mortality (pooled HR 0.25 [95% CI 0.12, 0.52]). Evidence was inconclusive with regard to other antirheumatic disease therapies, and the majority of other studies had a high risk of bias. Conclusion In this systematic review and meta‐analysis, hydroxychloroquine use was not associated with benefit or harm regarding COVID‐19 mortality. The evidence supporting the effect of other antirheumatic disease therapies in COVID‐19 is currently inconclusive.