Ultrasound carotid plaque features, cardiovascular disease risk factors and events: The Multi-Ethnic Study of Atherosclerosis

It is not known if ultrasound carotid plaque features are associated with cardiovascular disease (CVD) risk factors or if they predict future CVD events. We measured total carotid plaque area (TPA) and grayscale plaque features (grayscale median, black areas, and discrete white areas) by B-mode caro...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 2018-09, Vol.276, p.195-202
Main Authors: Mitchell, Carol, Korcarz, Claudia E., Gepner, Adam D., Kaufman, Joel D., Post, Wendy, Tracy, Russell, Gassett, Amanda J., Ma, Nanxun, McClelland, Robyn L., Stein, James H.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cardiovascular disease
Carotid Arteries - diagnostic imaging
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - ethnology
Carotid Intima-Media Thickness
Carotid ultrasound
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - ethnology
Coronary Disease - diagnosis
Coronary Disease - ethnology
Echogenicity
Female
Humans
Male
Middle Aged
Plaque
Plaque, Atherosclerotic
Predictive Value of Tests
Prevalence
Prognosis
Risk Assessment
Risk Factors
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is not known if ultrasound carotid plaque features are associated with cardiovascular disease (CVD) risk factors or if they predict future CVD events. We measured total carotid plaque area (TPA) and grayscale plaque features (grayscale median, black areas, and discrete white areas) by B-mode carotid ultrasound among 2205 participants who participated in the first (baseline) visit of the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to examine relationships between ultrasound plaque features and CVD risk factors at baseline. Cox proportional hazards models were used to assess if TPA, grayscale features, and carotid plaque score (number of arterial segments with a plaque) could predict incident coronary heart disease and cerebrovascular disease events over a mean follow-up of 13.3 years. Participants were mean (standard deviation [SD]) 65.4 (9.6) years, 49% male, 39% White, 11% Chinese, 28% Black, and 22% Hispanic. Mean TPA 27.7 (24.7) mm2, but no grayscale plaque features, was associated with CVD risk factors. In fully adjusted models, TPA but no grayscale features predicted incident coronary heart disease (CHD) events (HR 1.23; 95%CI 1.11–1.36; p
ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2018.06.005